Effects of nitroethane and 2-nitropropanol against Campylobacter jejuni

Date
2005-01-01
Authors
Horrocks, Shane
Jung, Yong Soo
Rilke, Steven
Callaway, Todd
Edrington, Thomas
Harvey, Roger
Anderson, Robin
Nisbet, David
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Campylobacter jejuni is an important foodborne pathogen that colonizes the gut of swine. In this study, the effects of nitroethane and 2-nitropropanol (0, 10 and 20 mM) on growth of C. jejuni were tested during culture in Bolton broth adjusted to pH of 5.6, 7.0 or 8.2. Viable cell counts of samples taken at intervals during incubation revealed main effects (P<0.0001) of nitroethane or 2-nitropropanol on mean specific growth rates thus demonstrating that these were inhibitory to C. jejuni. By 48 h of incubation, C. jejuni concentrations had increased by 1.9 log10 CFU/ml or higher in cultures containing no added nitrocompound.

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