Non-Animal Replacement Methods for Veterinary Vaccine Potency Testing: State of the Science and Future Directions Kulpa-Eddy, Jodie Srinivas, Geetha Roth, James Halder, Marlie Hill, Richard Brown, Karen Roth, James Draayer, Hans Galvin, Jeffrey Claassen, Ivo Gifford, Glen Woodland, Ralph Doelling, Vivan Jones, Brett Stokes, William
dc.contributor.department Veterinary Microbiology and Preventive Medicine 2018-02-17T04:45:50.000 2020-07-07T05:15:30Z 2020-07-07T05:15:30Z 2011-01-01
dc.description.abstract <p>NICEATM and ICCVAM convened an international workshop to review the state of the science of human and veterinary vaccine potency and safety testing methods and to identify opportunities to advance new and improved methods that can further reduce, refine, and replace animal use. Six topics were addressed in detail by speakers and workshop participants and are reported in a series of six reports. This workshop report, the second in the series, provides recommendations for current and future use of non-animal methods and strategies for veterinary vaccine potency testing. Workshop participants recommended that future efforts to replace animal use give priority to vaccines (1) that use large numbers of animals per test and for which many serials are produced annually, (2) that involve significant animal pain and distress during procedures, (3) for which the functional protective antigen has been identified, (4) that involve foreign animal/zoonotic organisms that are dangerous to humans, and (5) that involve pathogens that can be easily spread to wildlife populations. Vaccines identified as the highest priorities were those for rabies, <em>Leptospira spp</em>., <em>Clostridium spp</em>., Erysipelas, foreign animal diseases (FAD), poultry diseases, and fish diseases. Further research on the identification, purification, and characterization of vaccine protective antigens in veterinary vaccines was also identified as a priority. Workshop participants recommended priority research, development, and validation activities to address critical knowledge and data gaps, including opportunities to apply new science and technology. Recommendations included (1) investigations into the relative impact of various adjuvants on antigen quantification assays, (2) investigations into extraction methods that could be used for vaccines containing adjuvants that can interfere with antigen assays, and (3) review of the current status of rabies and tetanus human vaccine <em>in vitro</em>potency methods for their potential application to the corresponding veterinary vaccines. Workshop participants recommended enhanced international harmonization and cooperation and closer collaborations between human and veterinary researchers to expedite progress. Implementation of the workshop recommendations is expected to advance alternative <em>in vitro</em> methods for veterinary vaccine potency testing that will benefit animal welfare and replace animal use while ensuring continued protection of human and animal health.</p>
dc.description.comments <p>This article is from <em>Procedia in Vaccinology</em> 5 (2011): 60, doi:<a href="" id="x-ddDoi" target="_blank">10.1016/j.provac.2011.10.005</a>.</p>
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dc.identifier archive/
dc.identifier.articleid 1073
dc.identifier.contextkey 7792375
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/86
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 02:13:58 UTC 2022
dc.source.uri 10.1016/j.provac.2011.10.005
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords veterinary vaccines
dc.subject.keywords vaccine potency testing
dc.subject.keywords vaccine safety testing
dc.subject.keywords replacement alternatives
dc.subject.keywords ICCVAM
dc.title Non-Animal Replacement Methods for Veterinary Vaccine Potency Testing: State of the Science and Future Directions
dc.type article
dc.type.genre article
dspace.entity.type Publication
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