Nanoscale morphology of polyanhydride copolymers

Date
2005-01-01
Authors
Kipper, Matthew
Narasimhan, Balaji
Hou, Sheng-Shu
Seifert, Soenke
Thiyagarajan, Papannan
Schmidt-Rohr, Klaus
Narasimhan, Balaji
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Abstract

The microphase separation in polyanhydride random copolymers composed of 1,6-bis(p-carboxyphenoxy)hexane and sebacic acid is described. Though the copolymers are random, the monomers are sufficiently long and the segment-segment interaction parameter is sufficiently high to promote microphase separation when the copolymer is rich in one component. Solid-state NMR spin diffusion experiments and synchrotron small-angle X-ray scattering are used to discern the length scales of the microphase separation. Both techniques reveal a nanostructure with domain sizes less than 25 Ã…. This nanostructure is compared to approximate calculations of chain dimensions based on a random coil model and discussed in the context of the rational design of these materials for drug delivery applications.

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<p>Reprinted (adapted) with permission from <em>Macromolecules</em> 38 (2005): 8468, doi: <a href="http://dx.doi.org/10.1021/ma051267r" target="_blank">10.1021/ma051267r</a>. Copyright 2005 American Chemical Society.</p>
Keywords
NMR spin diffusion, polyanhydride copolymers, sebacic acid, small-angle x-ray scattering, morphology
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