Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

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2018-03-01
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Bouwman, Aniek
Garrick, Dorian
Reecy, James
Reecy, James
Van Tassell, Curtis
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Animal Science
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Animal Science
Abstract

Stature is affected by many polymorphisms of small effect in humans1. In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes2,3. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10−8) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP–seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.

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This article is published as Bouwman, Aniek C., Hans D. Daetwyler, Amanda J. Chamberlain, Carla Hurtado Ponce, Mehdi Sargolzaei, Flavio S. Schenkel, Goutam Sahana et al. "Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals." Nature genetics 50, no. 3 (2018): 362. doi: 10.1038/s41588-018-0056-5.

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