Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure

Date
2020-11-13
Authors
Minkler, Sarah
Lucien, Fabrice
Kimber, Michael
Bourgois-Mochel, Agnes
Musser, Margaret
Johannes, Chad
Frank, Igor
Cheville, John
Allenspach, Karin
Mochel, Jonathan
Journal Title
Journal ISSN
Volume Title
Publisher
Altmetrics
Authors
Research Projects
Organizational Units
Biomedical Sciences
Organizational Unit
Veterinary Clinical Sciences
Organizational Unit
Journal Issue
Series
Abstract

Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Due to high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. There is, therefore, a critical need to develop innovative molecular and cellular tools to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.

Description

This is a pre-print of the article Minkler, Sarah, Fabrice Lucien, Michael Kimber, Agnes Bourgois-Mochel, Margareth Musser, Chad Johannes, Igor Frank, John Cheville, Karin Allenspach, and Jonathan Mochel. "Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure." Preprints (2020). DOI: 10.20944/preprints202011.0364.v1. Posted with permission.

Keywords
Bladder Cancer, Exosomes, Organoids, One Health
Citation
DOI
Collections