Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure

dc.contributor.author Kimber, Michael
dc.contributor.author Minkler, Sarah
dc.contributor.author Lucien, Fabrice
dc.contributor.author Kimber, Michael
dc.contributor.author Mochel, Jonathan
dc.contributor.author Bourgois-Mochel, Agnes
dc.contributor.author Musser, Margaret
dc.contributor.author Johannes, Chad
dc.contributor.author Frank, Igor
dc.contributor.author Cheville, John
dc.contributor.author Allenspach, Karin
dc.contributor.author Mochel, Jonathan
dc.contributor.department Biomedical Sciences
dc.contributor.department Veterinary Clinical Sciences
dc.date 2020-11-18T20:40:02.000
dc.date.accessioned 2021-02-24T21:34:02Z
dc.date.available 2021-02-24T21:34:02Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.issued 2020-11-13
dc.description.abstract <p>Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years. Due to high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. There is, therefore, a critical need to develop innovative molecular and cellular tools to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.</p>
dc.description.comments <p>This is a pre-print of the article Minkler, Sarah, Fabrice Lucien, Michael Kimber, Agnes Bourgois-Mochel, Margareth Musser, Chad Johannes, Igor Frank, John Cheville, Karin Allenspach, and Jonathan Mochel. "Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure." <em>Preprints </em>(2020). DOI: <a href="https://doi.org/10.20944/preprints202011.0364.v1" target="_blank">10.20944/preprints202011.0364.v1</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/bms_pubs/90/
dc.identifier.articleid 1089
dc.identifier.contextkey 20233100
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath bms_pubs/90
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/93574
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/bms_pubs/90/2020_MochelJonathan_EmergingRoles.pdf|||Sat Jan 15 02:27:03 UTC 2022
dc.source.uri 10.20944/preprints202011.0364.v1
dc.subject.disciplines Medical Biochemistry
dc.subject.disciplines Translational Medical Research
dc.subject.disciplines Urology
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.keywords Bladder Cancer
dc.subject.keywords Exosomes
dc.subject.keywords Organoids
dc.subject.keywords One Health
dc.title Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure
dc.type article
dc.type.genre article
dspace.entity.type Publication
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