Characterization of Early Pathogenic Effects after Experimental Infection of Calves with Bovine Immunodeficiency-Like Virus
dc.contributor.author | Carpenter, Susan | |
dc.contributor.author | Roth, James | |
dc.contributor.author | Miller, Lyle | |
dc.contributor.author | Alexandersen, Soren | |
dc.contributor.author | Whetstone, Cecelia | |
dc.contributor.author | VanDerMaaten, Martin | |
dc.contributor.author | Viuff, Birgitte | |
dc.contributor.author | Wannemuehler, Yvonne | |
dc.contributor.author | Miller, Janice | |
dc.contributor.author | Roth, James | |
dc.contributor.department | Veterinary Microbiology and Preventive Medicine | |
dc.date | 2018-02-17T04:40:23.000 | |
dc.date.accessioned | 2020-07-07T05:15:16Z | |
dc.date.available | 2020-07-07T05:15:16Z | |
dc.date.issued | 1992-02-01 | |
dc.description.abstract | <p>The early pathogenic effects of bovine immunodeficiency-like virus (BIV) were studied in calves experimentally inoculated with BIV. All animals inoculated with BIV R29-infected cells seroconverted by 6 weeks postinoculation, and BIV was recoverable from each animal at 2 weeks postinoculation. However, levels of BIV replication in vivo appeared to be low. In situ hybridization studies indicated that during peak periods of viral replication in vivo, less than 0.03% of peripheral blood mononuclear cells were expressing detectable levels of viral RNA. Moreover, the levels of viral RNA in these cells in vivo were less than 1/10 the levels observed in persistently infected cells in vitro. BIV-inoculated calves had significantly higher numbers of circulating lymphocytes, and follicular hyperplasia was observed in lymph nodes, hemal nodes, and spleen. The histopathological changes observed in BIV-infected calves were similar to changes found early after infection with the immunosuppressive lentiviruses, including human immunodeficiency virus type 1.</p> | |
dc.description.comments | <p>This article is from <em>Journal of Virology</em> 66 (1992): 1074.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/vmpm_pubs/54/ | |
dc.identifier.articleid | 1057 | |
dc.identifier.contextkey | 7786513 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | vmpm_pubs/54 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/92360 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/vmpm_pubs/54/1992_Roth_CharacterizationEarly.pdf|||Sat Jan 15 00:53:00 UTC 2022 | |
dc.subject.disciplines | Veterinary Microbiology and Immunobiology | |
dc.subject.disciplines | Veterinary Pathology and Pathobiology | |
dc.subject.disciplines | Veterinary Preventive Medicine, Epidemiology, and Public Health | |
dc.title | Characterization of Early Pathogenic Effects after Experimental Infection of Calves with Bovine Immunodeficiency-Like Virus | |
dc.type | article | |
dc.type.genre | article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 909dd0b2-ec0a-41e2-b4e0-9e5ff76b7622 | |
relation.isOrgUnitOfPublication | 16f8e472-b1cd-4d8f-b016-09e96dbc4d83 |
File
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- 1992_Roth_CharacterizationEarly.pdf
- Size:
- 3.76 MB
- Format:
- Adobe Portable Document Format
- Description: