Characterization of Early Pathogenic Effects after Experimental Infection of Calves with Bovine Immunodeficiency-Like Virus Carpenter, Susan Roth, James Miller, Lyle Alexandersen, Soren Whetstone, Cecelia VanDerMaaten, Martin Viuff, Birgitte Wannemuehler, Yvonne Miller, Janice Roth, James
dc.contributor.department Veterinary Microbiology and Preventive Medicine 2018-02-17T04:40:23.000 2020-07-07T05:15:16Z 2020-07-07T05:15:16Z 1992-02-01
dc.description.abstract <p>The early pathogenic effects of bovine immunodeficiency-like virus (BIV) were studied in calves experimentally inoculated with BIV. All animals inoculated with BIV R29-infected cells seroconverted by 6 weeks postinoculation, and BIV was recoverable from each animal at 2 weeks postinoculation. However, levels of BIV replication in vivo appeared to be low. In situ hybridization studies indicated that during peak periods of viral replication in vivo, less than 0.03% of peripheral blood mononuclear cells were expressing detectable levels of viral RNA. Moreover, the levels of viral RNA in these cells in vivo were less than 1/10 the levels observed in persistently infected cells in vitro. BIV-inoculated calves had significantly higher numbers of circulating lymphocytes, and follicular hyperplasia was observed in lymph nodes, hemal nodes, and spleen. The histopathological changes observed in BIV-infected calves were similar to changes found early after infection with the immunosuppressive lentiviruses, including human immunodeficiency virus type 1.</p>
dc.description.comments <p>This article is from <em>Journal of Virology</em> 66 (1992): 1074.</p>
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dc.identifier archive/
dc.identifier.articleid 1057
dc.identifier.contextkey 7786513
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/54
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 00:53:00 UTC 2022
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Characterization of Early Pathogenic Effects after Experimental Infection of Calves with Bovine Immunodeficiency-Like Virus
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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