Bridgehead intermediates in organic synthesis. A reproducible synthesis of adamantane-containing compounds

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Date
1994-02-01
Authors
Kraus, George
Siclovan, Tiberiu
Kraus, George
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Chemistry
Abstract

Compounds containing the adamantane subunit have long been of interest to chemists due to the rigid structure and well-defined substitution chemistry of adamantane.l The discovery of the potent antiviral activity of amantadine (1-aminoadamantane) and rimantadine (a-methyl-l-adamantylmethylamine) has stimulated interest in the synthesis of adamantane-containing compounds.2 The significant neuroprotective properties of the NMDA antagonist memantine3 (l-amino-3,5-dimethyladamantane) have also prompted interest in adamantane synthesis

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Reprinted (adapted) with permission from The Journal of Organic Chemistry, 59(4); 922-923. Doi: 10.1021/jo00083a038. Copyright 1994 American Chemical Society.

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