A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice

dc.contributor.author Nickelson, Karen
dc.contributor.author Stromsdorfer, Kelly
dc.contributor.author Keating, Aileen
dc.contributor.author Pickering, R. Taylor
dc.contributor.author Liu, Tzu-Wen
dc.contributor.author Ortinau, Laura
dc.contributor.author Keating, Aileen
dc.contributor.author Perfield, James
dc.contributor.department Animal Science
dc.date 2019-09-19T10:54:35.000
dc.date.accessioned 2020-06-29T23:41:12Z
dc.date.available 2020-06-29T23:41:12Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2012
dc.date.issued 2012-01-01
dc.description.abstract <p>Expansion of intra-abdominal adipose tissue and the accompanying inflammatory response has been put forward as a unifying link between obesity and the development of chronic diseases. However, an apparent sexual dimorphism exists between obesity and chronic disease risk due to differences in the distribution and abundance of adipose tissue. A range of experimental protocols have been employed to demonstrate the role of estrogen in regulating health benefits; however, most studies are confounded by significant differences in body weight and adiposity. Therefore, the purpose of this study was to compare weight-matched obese male and female mice to determine if the sex-dependent health benefits remain when body weight is similar. The development of obesity in female mice receiving a high-fat diet was delayed; however, subsequent comparisons of weight-matched obese mice revealed greater adiposity in obese female mice. Despite excess adiposity and enlarged adipocyte size, obese females remained more glucose tolerant than weight-matched male mice, and this benefit was associated with increased expression of adiponectin and reductions in immune cell infiltration and oxidative stress in adipose tissue. Therefore, the protective benefits of estrogen persist in the obese state and appear to improve the metabolic phenotype of adipose tissue and the individual.</p>
dc.description.comments <p>This article is published as Nickelson, Karen J., Kelly L. Stromsdorfer, R. Taylor Pickering, Tzu-Wen Liu, Laura C. Ortinau, Aileen F. Keating, and James W. Perfield. "A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice." <em>Journal of Diabetes Research </em>2012 (2012): 859395. doi: <a href="http://dx.doi.org/10.1155/2012/859395">10.1155/2012/859395</a>.</p> <p>.</p>
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dc.identifier archive/lib.dr.iastate.edu/ans_pubs/485/
dc.identifier.articleid 1488
dc.identifier.contextkey 14994893
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/485
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9918
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/485/2012_Keating_ComparisonInflammatory.pdf|||Sat Jan 15 00:28:20 UTC 2022
dc.source.uri 10.1155/2012/859395
dc.subject.disciplines Animal Experimentation and Research
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Cellular and Molecular Physiology
dc.title A Comparison of Inflammatory and Oxidative Stress Markers in Adipose Tissue from Weight-Matched Obese Male and Female Mice
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication abe31007-187a-4174-864e-6871e3f9a0d7
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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