Genetic Modification of Pigs: Expanding their Utility as Biomedical Models

Abstract

<p>Development of transgenic animals has become technically more feasible over the past several decades creating opportunities for the genetic modification of numerous species. This dramatic expansion in the number of genetic modifications in pigs, in particular, is due to the advancement of molecular techniques that facilitate genetic modification as well as their agricultural importance and physiological characteristics, which make them an ideal model to conduct translational biomedical research. Genetic modification of pigs can address both basic and applied research questions with implications for agriculture and medicine.</p>