An overhanging 3' terminus is a conserved feature of telomeres

Date
1989
Authors
Henderson, Eric
Blackburn, Elizabeth
Henderson, Eric
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Zoology and Genetics
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Zoology and Genetics
Abstract

The reactivity of single-stranded thymidines with osmium tetraoxide was used to demonstrate the existence of a terminal overhang of the G-rich strand of telomeres from two distantly related eucaryotes, the ciliated protozoan Tetrahymena spp. and the acellular slime mold Didymium spp. Conservation of a G-strand overhang at the molecular terminus of telomeres is consistent with our suggestion that an unusual DNA structure formed by the G-strand overhang is important for telomere function (E. Henderson, C. C. Hardin, S. K. Wolk, I. Tinoco Jr., and E. H. Blackburn, Cell 51:899-908, 1987).

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This article is from Molecular and Cellular Biology 9 (1989): 345, doi: 10.1128/MCB.9.1.345. Posted with permission.

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