Many large lecture classes at undergraduate institutions have started to utilize technology to engage students. A mixed methods design was used in this dissertation research to build a comprehensive understanding of the statistical relationships among mathematics anxiety, math self-efficacy, and achievement in mathematics among students in a large lecture, undergraduate calculus class taught using clickers. The purpose of this study was to develop an understanding of the statistical relationships and of the students’ experiences and perspectives on the relationships among mathematics self-efficacy, math anxiety, and achievement, along with the effect of clicker use on these variables, with attention given to changes in student perceptions during the semester. Statistical analysis was conducted utilizing quantitative survey data, and qualitative methods were used to analyze student interview data. Pairwise statistical relationships identified in previous research were confirmed among math anxiety, mathematics self-efficacy, and achievement in mathematics. Findings also revealed the potential for clickers to help promote desired learning outcomes when used effectively by students and instructors. Future research on the effect of clicker use in other types of mathematics courses besides calculus, in classes with students representing a more diverse range of racial/ethnic backgrounds, and with smaller class sizes will help build on the knowledge gained from this study.