Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog

Date
2018-01-01
Authors
Smith, Jodi
Loewen, Jennifer
Cianciolo, Rachel
Zhang, Liwen
Yaeger, Michael
Ward, Jessica
Ward, Jessica
Smith, Jodi
LeVine, Dana
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Veterinary Pathology
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Veterinary Clinical Sciences
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Veterinary PathologyVeterinary Clinical Sciences
Abstract

Thymoma‐associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7‐year‐old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. The dog was diagnosed with azotemia, marked proteinuria, and a thymoma that was surgically removed. Postoperatively, the dog developed a large left ventricular thrombus and was euthanized. Necropsy confirmed the presence of a left ventricular thrombus and histopathology revealed renal amyloidosis. We speculate that the renal amyloidosis occurred secondary to the thymoma, with amyloidosis in turn leading to nephrotic syndrome, hypercoagulability, and ventricular thrombosis. This case illustrates the potential for thymoma‐associated nephropathies to occur in dogs and that dogs suspected to have thymoma should have a urinalysis and urine protein creatinine ratio performed as part of the pre‐surgical database.

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This article is published as Loewen, Jennifer M., Rachel E. Cianciolo, Liwen Zhang, Michael Yaeger, Jessica L. Ward, Jodi D. Smith, and Dana N. LeVine. "Concurrent renal amyloidosis and thymoma resulting in a fatal ventricular thrombus in a dog." Journal of veterinary internal medicine (2018). doi: 10.1111/jvim.15062.

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