AC/DC differential bridge based solution-electrode interfacial capacitance biosensor, for field-deployable real-time and low-cost detection of MCLR in drinking water.

dc.contributor.advisor Nathan M. Neihart
dc.contributor.author Neshani, Sara
dc.contributor.department Electrical and Computer Engineering
dc.date 2020-02-12T22:58:55.000
dc.date.accessioned 2020-06-30T03:20:42Z
dc.date.available 2020-06-30T03:20:42Z
dc.date.copyright Sun Dec 01 00:00:00 UTC 2019
dc.date.embargo 2020-06-02
dc.date.issued 2019-01-01
dc.description.abstract <p>Microcystin-LR (MCLR, one of the most toxic and commonly found products of cyanobacteria in freshwater resources, threatens human health and the livestock. WHO has set a standard limit of 1 μg⁄l for the concentration of MCLR in drinking water. The lab-based, specialized water quality monitoring tests for this purpose are not only expensive but also slow and require sample preparation and transportation from distant sites. Therefore, there is a need for a handheld, field-deployable and low-cost biosensor to make frequent water quality monitoring easier.</p> <p>Many field-deployable biosensors with applications in environmental monitoring and healthcare where concentrations of interest are on the order of μg/l and fewer face challenges in achieving high dynamic range and lower detection resolution due to the resultant small fractional change in the transducer characteristics. Additionally, non-faradaic label-free biosensors for MCLR type applications face difficulty in real-time data analysis due to signal drift, non-specific binding of non-target particles and last but not least noise coming from both transducer and readout electronics.</p> <p>This dissertation is mainly focused on utilizing electronic circuit methods to fill the gap of reading small responses from the bio-transducer with sufficient accuracy and sensitivity. Differential bridge based transduction as sensitivity booster and careful design of amplification unit and real-time signal processing capable of extracting signal information buried in noise are part of the presented work that achieves 8-bit resolution within a 1% full-scale transducer fractional capacitive change.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/etd/17756/
dc.identifier.articleid 8763
dc.identifier.contextkey 16525085
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath etd/17756
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/31939
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/etd/17756/Neshani_iastate_0097E_18569.pdf|||Fri Jan 14 21:28:32 UTC 2022
dc.subject.disciplines Electrical and Electronics
dc.subject.keywords capacitive bisensor
dc.subject.keywords differential electrochemical capacitive bridge
dc.subject.keywords field-deployable
dc.subject.keywords low-cost
dc.subject.keywords microcystine-LR (MCLR)
dc.subject.keywords real-time
dc.title AC/DC differential bridge based solution-electrode interfacial capacitance biosensor, for field-deployable real-time and low-cost detection of MCLR in drinking water.
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication a75a044c-d11e-44cd-af4f-dab1d83339ff
thesis.degree.discipline Electrical Engineering
thesis.degree.level dissertation
thesis.degree.name Doctor of Philosophy
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