Kinetics of UV254 inactivation of selected viral pathogens in a static system

dc.contributor.author Cutler, T.
dc.contributor.author Wang, C.
dc.contributor.author Qin, Q.
dc.contributor.author Zhou, F.
dc.contributor.author Warren, K.
dc.contributor.author Hoff, Steven
dc.contributor.author Yoon, K.-J.
dc.contributor.author Hoff, S.
dc.contributor.author Ridpath, J.
dc.contributor.author Zimmerman, J.
dc.contributor.department Statistics
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.contributor.department Agricultural and Biosystems Engineering
dc.date 2018-02-17T15:54:54.000
dc.date.accessioned 2020-07-07T05:13:33Z
dc.date.available 2020-07-07T05:13:33Z
dc.date.issued 2011-08-01
dc.description.abstract <p><strong>Aims: </strong> The objective of this study was to estimate UV<sub>254</sub> inactivation constants for four viral pathogens: influenza virus type A, porcine respiratory and reproductive syndrome virus (PRRSV), bovine viral diarrhoea virus (BVDV) and reovirus.</p> <p><strong>Methods and Results: </strong> Viruses in culture medium were exposed to one of nine doses of UV<sub>254</sub> and then titrated for infectious virus. Analysis showed that viral inactivation by UV<sub>254</sub> was more accurately described by a two-stage inactivation model <em>vs</em> a standard one-stage inactivation model.</p> <p><strong>Conclusions: </strong> The results provided evidence for the existence of two heterogeneous viral subpopulations among the viruses tested, one highly susceptible to UV<sub>254</sub> inactivation and the other more resistant. Importantly, inactivation constants based on the one-stage inactivation model would have underestimated the UV<sub>254</sub> dose required for the inactivation of these viruses under the conditions of the experiment.</p> <p><strong>Significance and Impact of the Study: </strong> To improve the accuracy of estimates, it is recommended that research involving the inactivation of micro-organisms evaluates inactivation kinetics using both one-stage and two-stage models. These results will be of interest to persons responsible for microbial agents under laboratory or field conditions.</p>
dc.description.comments <p>This article is from <em>Journal of Applied Microbiology</em> 111 (2011): 389–395, doi:<a href="http://dx.doi.org/10.1111/j.1365-2672.2011.05046.x" target="_blank">10.1111/j.1365-2672.2011.05046.x</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vdpam_pubs/65/
dc.identifier.articleid 1045
dc.identifier.contextkey 8442771
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vdpam_pubs/65
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92093
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_pubs/65/2011_Cutler_KineticsUV254.pdf|||Sat Jan 15 01:23:37 UTC 2022
dc.source.uri 10.1111/j.1365-2672.2011.05046.x
dc.subject.disciplines Animal Diseases
dc.subject.disciplines Biometry
dc.subject.disciplines Bioresource and Agricultural Engineering
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.keywords PRRSV
dc.subject.keywords Two stage
dc.subject.keywords Ultraviolet
dc.subject.keywords UV inactivation
dc.title Kinetics of UV254 inactivation of selected viral pathogens in a static system
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 98b46d48-66a2-4458-9b42-8c4aa050664d
relation.isOrgUnitOfPublication 264904d9-9e66-4169-8e11-034e537ddbca
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
relation.isOrgUnitOfPublication 5ab07352-4171-4f53-bbd7-ac5d616f7aa8
relation.isOrgUnitOfPublication 8eb24241-0d92-4baf-ae75-08f716d30801
File
Original bundle
Now showing 1 - 1 of 1
Name:
2011_Cutler_KineticsUV254.pdf
Size:
512.34 KB
Format:
Adobe Portable Document Format
Description:
Collections