Jil-1, a Chromosomal Kinase Implicated in Regulation of Chromatin Structure, Associates with the Male Specific Lethal (Msl) Dosage Compensation Complex

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2000-05-29
Authors
Jin, Ye
Wang, Yanming
Johansen, Kristen
Johansen, Jorgen
Johansen, Kristen
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Zoology and Genetics
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Zoology and Genetics
Abstract

JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL-1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.

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This article is published as Jin, Ye, Yanming Wang, Jørgen Johansen, and Kristen M. Johansen. "JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex." The Journal of cell biology 149, no. 5 (2000): 1005-1010. doi: 10.1083/jcb.149.5.1005. Posted with permission.

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