High-molecular weight compounds of nitrogen and sulfur as therapeutic agents

dc.contributor.author Massie, Samuel
dc.contributor.department Chemistry
dc.date 2018-08-23T08:04:58.000
dc.date.accessioned 2020-06-30T07:26:45Z
dc.date.available 2020-06-30T07:26:45Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 1946
dc.date.issued 1946
dc.description.abstract <p>General reviews of the chemotherapy of malaria and tuberculosis have been made;A survey of the physiological properties and therapeutic uses of compounds containing high-molecular weight aliphatic groups has been given;The large amount of lipoidal tissue present in certain strains of bacteria, such as the tubercle bacillus, suggested that the introduction into potential physiologically-active structures of groups which would be lipoidal-soluble might give rise to valuable medicinals. This thought initiated the study and preparation of nitrogen and sulfur compounds containing high-molecular weight aliphatic groups as therapeutic agents;Several nitrogen derivatives have been made for therapeutic testing, These agents include dibutylalkylamines derivatives of tetradecylamine and hexadecylamine. Rearrangement has been shown to occur during the reaction between alpha-halogenonaphthalenes and lithium dialkylamides, beta-dialkylaminonaphthalenes being formed;Several sulfur derivatives containing high-molecular weight aliphatic groups have been prepared for pharmacological testing. These compounds include quinolyl dodecyl sulfides, hydroxy sulfides, imidosulfides and sulfur-containing mercurials;The reaction between laurophenone and phosphorus pentachloride has been shown to give 1-phenyl-1-chlorododeceno-1 in good yield;Several miscellaneous compounds have been prepared for physiological testing. These compounds include anils derived from 1-diethylamino-4-aminopentane, substituted cinchoninic acids and phenothiazine derivatives;Complete pharmacological results are not available, but none of the commands on which reports have been received has shown any significant therapeutic activity.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/rtd/13173/
dc.identifier.articleid 14172
dc.identifier.contextkey 6882737
dc.identifier.doi https://doi.org/10.31274/rtd-180813-14536
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath rtd/13173
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/66622
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/rtd/13173/r_DP12391.pdf|||Fri Jan 14 19:46:12 UTC 2022
dc.subject.disciplines Organic Chemistry
dc.subject.keywords Chemotherapy
dc.subject.keywords Antibiotics
dc.title High-molecular weight compounds of nitrogen and sulfur as therapeutic agents
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
thesis.degree.level dissertation
thesis.degree.name Doctor of Philosophy
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