The Major Histocompatibility Complex and its Role in Disease Resistance and Immune Responsiveness Rothschild, Max Skow, L. Lamont, S. J. Lamont, Susan
dc.contributor.department Animal Science 2018-05-23T08:58:21.000 2020-06-29T23:40:38Z 2020-06-29T23:40:38Z Sat Jan 01 00:00:00 UTC 2000 2000-01-01
dc.description.abstract <p>Central to an animal's defence system is the ability to differentiate self from non-self and, thus, protect itself from disease. This unique quality is determined, in large part, by the major histocompatibility complex (MHC) genes of each species. In farm animals, the knowledge of the MHC genes has been growing, especially since the rapid advances in molecular biology. The general structure of the MHC of the pig, cow, chicken and horse is presented in this chapter. Disease and immune response associations are also described. Although in many instances these data are limited, it is clear that the MHC is strongly associated with health traits in farm animals. Understanding these MHC-disease resistance and immune-responsiveness relationships will allow genetic improvement to be made by marker-assisted selection, rather than by direct challenge of populations with pathogens.</p>
dc.description.comments <p>This is a chapter from Rothschild, M. F., L. Skow, and S.J. Lamont. 2000. The major histocompatibility complex and its role in disease resistance and immune responsiveness. In: Breeding for Disease Resistance in Farm Animals, Edition 2. CABI Press. pp. 73-105. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 1414
dc.identifier.contextkey 12137973
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/414
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 00:10:53 UTC 2022
dc.source.bitstream archive/|||Sat Jan 15 00:10:55 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.title The Major Histocompatibility Complex and its Role in Disease Resistance and Immune Responsiveness
dc.type article
dc.type.genre book_chapter
dspace.entity.type Publication
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isAuthorOfPublication 5dee3d24-aa7a-4fe1-abf6-f0bb615bfe24
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
15.93 MB
Adobe Portable Document Format
No Thumbnail Available
239.26 KB
Adobe Portable Document Format