Antimicrobial peptides in animals and their role in host defences Brogden, Kim Ackermann, Mark Ackermann, Mark McCray, Paul Tack, Brian
dc.contributor.department Veterinary Pathology 2018-02-13T06:24:56.000 2020-07-07T05:15:53Z 2020-07-07T05:15:53Z 2013-02-26 2003-01-01
dc.description.abstract <p>Domesticated animals have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. These peptides differ in size, composition, mechanisms of activity and range of antimicrobial specificities. They are expressed in many tissues, polymorphonuclear leukocytes, macrophages and mucosal epithelial cells. There is a small group of anionic antimicrobial peptides found in ruminants and a much larger group of cationic antimicrobial peptides found in all domesticated animals. The cationic peptides include linear, helical peptides, linear peptides rich in proline and cysteine-stabilized peptides with a b-sheet and are commonly referred to as cathelicidins and defensins. These peptides are generally broad-spectrum for Gram-positive bacteria, Gram-negative bacteria and fungi (e.g. myeloid antimicrobial peptides, a-, b-defensins, and protegrins) or are specific to one of these groups (e.g. porcine cecropin P1, Bac5, Bac7, PR-39 and prophenin).</p>
dc.description.comments <p>This article is from <em>International Journal of Antimicrobial Agents </em>22 (2003): 465–478, doi:<a href="" target="_blank">10.1016/S0924-8579(03)00180-8</a>.</p>
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dc.identifier archive/
dc.identifier.articleid 1036
dc.identifier.contextkey 3790755
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/37
dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 23:48:55 UTC 2022
dc.source.uri 10.1016/S0924-8579(03)00180-8
dc.subject.disciplines Microbiology
dc.subject.disciplines Pediatrics
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.keywords Antimicrobial peptides
dc.subject.keywords Domesticated Animals
dc.subject.keywords Livestock
dc.subject.keywords Innate defense
dc.subject.keywords Defensins
dc.subject.keywords Cathelicidins
dc.subject.keywords Anionic peptides
dc.subject.keywords Cationic peptides
dc.title Antimicrobial peptides in animals and their role in host defences
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
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