Comparative efficacy of antimicrobials for treatment of clinical mastitis in lactating dairy cattle: a systematic review and network meta-analysis
dc.contributor.author | O'Connor, Annette | |
dc.contributor.author | Wang, Chong | |
dc.contributor.author | Hu, Dapeng | |
dc.contributor.author | Wang, Chong | |
dc.contributor.author | Kelton, David | |
dc.contributor.author | Godkin, M. A. | |
dc.contributor.author | Churchill, Katheryn | |
dc.contributor.author | O’Connor, Annette | |
dc.contributor.department | Veterinary Diagnostic and Production Animal Medicine | |
dc.date | 2020-02-28T16:07:58.000 | |
dc.date.accessioned | 2020-07-07T05:13:06Z | |
dc.date.available | 2020-07-07T05:13:06Z | |
dc.date.copyright | Wed Jan 01 00:00:00 UTC 2020 | |
dc.date.issued | 2019-12-01 | |
dc.description.abstract | <p>A systematic review and network meta-analysis were conducted to assess the relative efficacy of antimicrobial therapy for clinical mastitis in lactating dairy cattle. Controlled trials in lactating dairy cattle with natural disease exposure were eligible if they compared an antimicrobial treatment to a non-treated control, placebo, or a different antimicrobial, for the treatment of clinical mastitis, and assessed clinical or bacteriologic cure. Potential for bias was assessed using a modified Cochrane Risk of Bias 2.0 tool. From 14775 initially identified records, 54 trials were assessed as eligible. Networks were established for bacteriologic cure by bacterial species group, and clinical cure. Disparate networks among bacteriologic cures precluded meta-analysis. Network meta-analysis was conducted for trials assessing clinical cure, but lack of precision of point estimates resulted in wide credibility intervals for all treatments, with no definitive conclusions regarding relative efficacy. Consideration of network geometry can inform future research to increase the utility of current and previous work. Replication of intervention arms and consideration of connection to existing networks would improve the future ability to determine relative efficacy. Challenges in the evaluation of bias in primary research stemmed from a lack of reporting. Consideration of reporting guidelines would also improve the utility of future research.</p> | |
dc.description.comments | <p>This article is published as Winder, C. B., J. M. Sargeant, D. Hu, C. Wang, D. F. Kelton, M. A. Godkin, K. J. Churchill, and A. M. O'Connor. "Comparative efficacy of antimicrobials for treatment of clinical mastitis in lactating dairy cattle: a systematic review and network meta-analysis." <em>Animal Health Research Reviews</em> 20, no. 2 (2019): 229-246. DOI: <a href="http://dx.doi.org/10.1017/S1466252319000318" target="_blank">10.1017/S1466252319000318</a>. Posted with permission.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/vdpam_pubs/176/ | |
dc.identifier.articleid | 1189 | |
dc.identifier.contextkey | 16679930 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | vdpam_pubs/176 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/92022 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/vdpam_pubs/176/2019_OConnorAnnette_ComparativeEfficacyAntimicrobials.pdf|||Fri Jan 14 21:26:11 UTC 2022 | |
dc.source.uri | 10.1017/S1466252319000318 | |
dc.subject.disciplines | Large or Food Animal and Equine Medicine | |
dc.subject.disciplines | Veterinary Microbiology and Immunobiology | |
dc.subject.disciplines | Veterinary Preventive Medicine, Epidemiology, and Public Health | |
dc.subject.keywords | Dairy cow | |
dc.subject.keywords | mixed treatment comparison | |
dc.subject.keywords | udder health | |
dc.title | Comparative efficacy of antimicrobials for treatment of clinical mastitis in lactating dairy cattle: a systematic review and network meta-analysis | |
dc.type | article | |
dc.type.genre | article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | bbd2db96-9105-4b96-8f96-713be18a75ac | |
relation.isAuthorOfPublication | b715071c-c3bd-419c-b021-0ac4702f346a | |
relation.isOrgUnitOfPublication | 5ab07352-4171-4f53-bbd7-ac5d616f7aa8 |
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