Impaired Fitness and Transmission of Macrolide-Resistant Campylobacter jejuni in Its Natural Host

dc.contributor.author Luangtongkum, Taradon
dc.contributor.author Shen, Zhangqi
dc.contributor.author Seng, Virginia
dc.contributor.author Zhang, Qijing
dc.contributor.author Sahin, Orhan
dc.contributor.author Jeon, Byeonghwa
dc.contributor.author Liu, Peng
dc.contributor.author Zhang, Qijing
dc.contributor.department Statistics
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-18T23:26:32.000
dc.date.accessioned 2020-07-07T05:14:41Z
dc.date.available 2020-07-07T05:14:41Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2012
dc.date.issued 2012-03-01
dc.description.abstract <p>Campylobacter jejuni is a major zoonotic pathogen transmitted to humans via the food chain and is prevalent in chickens, a natural reservoir for this pathogenic organism. Due to the importance of macrolide antibiotics in clinical therapy of human campylobacteriosis, development of macrolide resistance in Campylobacter has become a concern for public health. To facilitate the control of macrolide-resistant Campylobacter, it is necessary to understand if macrolide resistance affects the fitness and transmission of Campylobacter in its natural host. In this study we conducted pairwise competitions and comingling experiments in chickens using clonally related and isogenic C. jejuni strains, which are either susceptible or resistant to erythromycin (Ery). In every competition pair, Ery-resistant (Ery<sup>r</sup>) Campylobacter was consistently outcompeted by the Ery-susceptible (Ery<sup>s</sup>) strain. In the comingling experiments, Ery<sup>r</sup> Campylobacter failed to transmit to chickens precolonized by Ery<sup>s</sup> Campylobacter, while isogenic Ery<sup>s</sup> Campylobacter was able to transmit to and establish dominance in chickens precolonized by Ery<sup>r</sup> Campylobacter. The fitness disadvantage was linked to the resistance-conferring mutations in the 23S rRNA. These findings clearly indicate that acquisition of macrolide resistance impairs the fitness and transmission of Campylobacter in chickens, suggesting that the prevalence of macrolide-resistant C. jejuni will likely decrease in the absence of antibiotic selection pressure.</p>
dc.description.comments <p>This article is published as Luangtongkum, Taradon, Zhangqi Shen, Virginia W. Seng, Orhan Sahin, Byeonghwa Jeon, Peng Liu, and Qijing Zhang. "Impaired fitness and transmission of macrolide-resistant Campylobacter jejuni in its natural host." Antimicrobial agents and chemotherapy 56, no. 3 (2012): 1300-1308. doi: <a href="http://dx.doi.org/10.1128/AAC.05516-11%20" target="_blank" title=" Impaired Fitness and Transmission of Macrolide-Resistant Campylobacter jejuni in Its Natural Host ">10.1128/AAC.05516-11</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/162/
dc.identifier.articleid 1162
dc.identifier.contextkey 10836457
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/162
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92268
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/162/2012_Zhang_ImpairedFitness.pdf|||Fri Jan 14 20:56:33 UTC 2022
dc.source.uri 10.1128/AAC.05516-11
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Statistical Methodology
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Impaired Fitness and Transmission of Macrolide-Resistant Campylobacter jejuni in Its Natural Host
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 1c6a5dfc-c604-457f-85be-122910db782e
relation.isOrgUnitOfPublication 264904d9-9e66-4169-8e11-034e537ddbca
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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