Current diagnostics for chronic enteropathies in dogs

Date
2021-10-26
Authors
Allenspach, Karin
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Wiley Periodicals LLC
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Biomedical SciencesVeterinary Diagnostic and Production Animal MedicineVeterinary Clinical Sciences
Abstract
Chronic enteropathies (CEs) in dogs describe a group of idiopathic disorders characterized by chronic persistent or recurrent gastrointestinal (GI) signs. Three major subgroups of CE can be identified by their response to treatment: Food-responsive disease (FRD), antibiotic-responsive disease (ARD), and steroid-responsive disease (SRD). The clinical diagnosis of CE is made by exclusion of all other possible causes of chronic diarrhea and includes histologic assessment of intestinal biopsies. The process of diagnosing canine CE can therefore be very time-consuming and expensive, and in most cases, does not help to identify dogs that will respond to a specific treatment. The development of novel diagnostic tests for canine CE has therefore focused on the accuracy of such tests to predict treatment responses. In this article, several novel assays that have the potential to become commercially available will be discussed, such as genetic tests, perinuclear anti-neutrophil cytoplasmic antibodies (pANCA), antibodies against transglutaminase/gliadin, antibodies against E coli OmpC/flagellin, and micro RNAs.
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This is the published version of the following article: Allenspach, Karin, and Jonathan P. Mochel. "Current diagnostics for chronic enteropathies in dogs." Veterinary Clinical Pathology (2021). DOI: 10.1111/vcp.13068. Attribution 4.0 International (CC BY 4.0). Copyright 2021 The Authors. Posted with permission.
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chronic, diagnostic markers, dog, enteropathy, gastroenterology, immunology
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