Humanitarian Information Systems (HIS) are of great importance in crisis times because relief organizations need accurate and timely information to respond and meet the affected population's needs. The more relief organizations can collect, process, analyze, and disseminate information, the more effective the response will be. Humanitarian organizations worldwide rely on Information and Communication Technology (ICT) for communication, coordination, and decision-making regarding distributing reliefs to the affected people. This study highlights some of the challenges of information systems in humanitarian work. It provides a guide that may assist humanitarian relief organizations in managing their information systems in a way that enables them to respond to crises better.