Genome Analysis and Phylogenetic Relatedness of Gallibacterium anatis Strains from Poultry Johnson, Timothy Nolan, Lisa Danzeisen, Jessica Trampel, Darrell Nolan, Lisa Seemann, Torsten Bager, Ragnhild Bojesen, Anders
dc.contributor.department Veterinary Microbiology and Preventive Medicine 2018-02-13T10:26:31.000 2020-07-07T05:14:57Z 2020-07-07T05:14:57Z Tue Jan 01 00:00:00 UTC 2013 2013-05-03 2013-01-24
dc.description.abstract <p>Peritonitis is the major disease problem of laying hens in commercial table egg and parent stock operations. Despite its importance, the etiology and pathogenesis of this disease have not been completely clarified. Although avian pathogenic <em>Escherichia coli</em> (APEC) isolates have been incriminated as the causative agent of laying hen peritonitis, <em>Gallibacterium anatis</em> are frequently isolated from peritonitis lesions. Despite recent studies suggesting a role for <em>G. anatis</em> in the pathogenesis of peritonitis, little is known about the organism’s virulence mechanisms, genomic composition and population dynamics. Here, we compared the genome sequences of three <em>G. anatis</em> isolates in an effort to understand its virulence mechanisms and identify novel antigenic traits. A multilocus sequence typing method was also established for <em>G. anatis</em> and used to characterize the genotypic relatedness of 71 isolates from commercial laying hens in Iowa and 18 international reference isolates. Genomic comparisons suggest that<em>G. anatis</em> is a highly diverse bacterial species, with some strains possessing previously described and potential virulence factors, but with a core genome containing several antigenic candidates. Multilocus sequence typing effectively distinguished 82 sequence types and several clonal complexes of <em>G. anatis</em>, and some clones seemed to predominate among <em>G. anatis</em> populations from commercial layers in Iowa. Biofilm formation and resistance to antimicrobial agents was also observed in several clades. Overall, the genomic diversity of <em>G. anatis</em> suggests that multiple lineages exist with differing pathogenic potential towards birds.</p>
dc.description.comments <p>This article is from <em>PLoS ONE </em>8, no. 1 (2013): e54844, doi:<a href="" target="_blank">10.1371/journal.pone.0054844</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 1002
dc.identifier.contextkey 4106654
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/2
dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 22:02:02 UTC 2022
dc.source.uri 10.1371/journal.pone.0054844
dc.subject.disciplines Genomics
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Genome Analysis and Phylogenetic Relatedness of Gallibacterium anatis Strains from Poultry
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 9e7506b4-e945-47cf-9195-e814dac6c9fd
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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