Preparatory Work for the Future Development of Scientific Opinions on Animal Health

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dc.contributor.author O'Connor, Annette
dc.contributor.author O'Connor, Annette
dc.contributor.author Dzikamunhenga, Rungano
dc.contributor.author Wolfe, D.
dc.contributor.author Sargeant, Jan
dc.contributor.author Glanville, J.
dc.contributor.author Wood, J
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2018-02-17T02:06:44.000
dc.date.accessioned 2020-07-07T05:13:58Z
dc.date.available 2020-07-07T05:13:58Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2015
dc.date.embargo 2015-09-30
dc.date.issued 2015-01-01
dc.description.abstract <p>This final report summarizes the results of two reviews and a scoping study related to Canine leishmaniosis (CanL). Three objectives were addressed in this project. Objective 1 was to summarize relative sensitivity and specificity estimates of assays used to detect infection in dogs with Leishmania infantum in studies of naïve dogs in areas where Leishmania infantum infection is endemic. Objective 2 was to summarize data available to estimate the prevalence of parasitological cure (failure to detect organism) after a 12-month follow-up period in animals treated with meglumine antimoniate, miltefosine, and allopurinol or combinations of these drugs for canine leishmaniosis. Objective 3 was to assess diagnostic test characteristics of PCR assays and serological assays (ELISA or IFAT) from studies that use experimental models of Canine leishmaniosis. The same comprehensive search was used for all objectives. The searches yielded 7,405 records. After duplicates were removed, 3,865 records remained. Of these, 243 were broadly identified as diagnostic test evaluation studies and at the 2nd level of screening 18 were considered longitudinal studies. The 18 references were then assessed based on the full text and 7 were considered relevant to the review. The assays assessed by these studies were PCR on skin, buffy coat, bone marrow, blood and conjunctiva, and IFAT and ELISA. For objective 2, 40 potentially relevant records were identified as treatment comparison studies. After full-text screening, 13 studies were included in the review. The treatments varied greatly, and few comparative efficacy estimates were provided. No treatment was associated with 100% cure after 180 days follow-up. For objective 3, 513 citations were identified and the full texts of 169 articles were obtained. Sixty-two articles described at least one of the assays requested (PCR, ELISA or IFAT) and 18 articles described the use of a PCR and either ELISA and/or IFAT.</p>
dc.description.comments <p>This report is <em>IFSA Supporting Publications </em> (2015): EN-761, 95 pp. Available online: <a href="http://www.efsa.europa.eu/publications" target="_blank">www.efsa.europa.eu/publications</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vdpam_reports/4/
dc.identifier.articleid 1002
dc.identifier.contextkey 7661376
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vdpam_reports/4
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92149
dc.language.iso en
dc.relation.ispartofseries 2015:EN-761
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_reports/4/2014_OConnor_PreparatoryWork.pdf|||Sat Jan 15 00:00:20 UTC 2022
dc.subject.disciplines Comparative and Laboratory Animal Medicine
dc.subject.disciplines Laboratory and Basic Science Research
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords Dogs
dc.subject.keywords diagnostic tests
dc.subject.keywords protocol
dc.subject.keywords scoping review
dc.subject.keywords Leishmania infantum
dc.subject.keywords treatment
dc.title Preparatory Work for the Future Development of Scientific Opinions on Animal Health
dc.type article
dc.type.genre report
dspace.entity.type Publication
relation.isAuthorOfPublication bbd2db96-9105-4b96-8f96-713be18a75ac
relation.isOrgUnitOfPublication 5ab07352-4171-4f53-bbd7-ac5d616f7aa8
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