Respiratory Syncytial Virus Infection in Cattle Sacco, R. McGill, J. Ackermann, Mark Pillatzki, A. Palmer, M. Ackermann, M.
dc.contributor.department Veterinary Pathology 2018-02-17T18:22:23.000 2020-07-07T05:16:09Z 2020-07-07T05:16:09Z 2014-03-01
dc.description.abstract <p>Bovine respiratory syncytial virus (RSV) is a cause of respiratory disease in cattle worldwide. It has an integral role in enzootic pneumonia in young dairy calves and summer pneumonia in nursing beef calves. Furthermore, bovine RSV infection can predispose calves to secondary bacterial infection by organisms such as<em>Mannheimia haemolytica</em>, <em>Pasteurella multocida</em>, and <em>Histophilus somni</em>, resulting in bovine respiratory disease complex, the most prevalent cause of morbidity and mortality among feedlot cattle. Even in cases where animals do not succumb to bovine respiratory disease complex, there can be long-term losses in production performance. This includes reductions in feed efficiency and rate of gain in the feedlot, as well as reproductive performance, milk production, and longevity in the breeding herd. As a result, economic costs to the cattle industry from bovine respiratory disease have been estimated to approach $1 billion annually due to death losses, reduced performance, and costs of vaccinations and treatment modalities. Human and bovine RSV are closely related viruses with similarities in histopathologic lesions and mechanisms of immune modulation induced following infection. Therefore, where appropriate, we provide comparisons between RSV infections in humans and cattle. This review article discusses key aspects of RSV infection of cattle, including epidemiology and strain variability, clinical signs and diagnosis, experimental infection, gross and microscopic lesions, innate and adaptive immune responses, and vaccination strategies.</p>
dc.description.comments <p>This article is from <em>Veterinary Pathology</em> 51 (2014): 427–436, doi:<a href="" target="_blank">10.1177/0300985813501341</a>.</p>
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dc.identifier archive/
dc.identifier.articleid 1081
dc.identifier.contextkey 8805959
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/80
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 02:04:42 UTC 2022
dc.source.uri 10.1177/0300985813501341
dc.subject.disciplines Animal Diseases
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.keywords Respiratory syncytial virus
dc.subject.keywords Cattle
dc.subject.keywords Epidemiology
dc.subject.keywords Diagnosis
dc.subject.keywords Pathology
dc.subject.keywords Innate immunity
dc.subject.keywords Acquired immunity
dc.subject.keywords Vaccines
dc.title Respiratory Syncytial Virus Infection in Cattle
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
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