Pulmonary and Serum Antibody Responses Elicited in Zebu Cattle Experimentally Infected with Mycoplasma mycoides Subsp. mycoides SC by Contact Exposure

dc.contributor.author Niang, Mamadou
dc.contributor.author Diallo, Mahamadou
dc.contributor.author Roth, James
dc.contributor.author Cisse, Ousmane
dc.contributor.author Kone, Mamadou
dc.contributor.author Doucoure, Modibo
dc.contributor.author Roth, James
dc.contributor.author Balcer-Rodrigues, Valérie
dc.contributor.author Dedieu, Laurence
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-17T04:44:56.000
dc.date.accessioned 2020-07-07T05:15:19Z
dc.date.available 2020-07-07T05:15:19Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2006
dc.date.issued 2006-01-01
dc.description.abstract <p>The purpose of the present study was to characterize the Mycoplasma mycoides subsp. mycoides small colony (MmmSC)-specific humoral immune response at both systemic and local levels in cattle experimentally infected with MmmSC, for a better understanding of the protective immune mechanisms against the disease. The disease was experimentally reproduced in zebu cattle by contact. Clinical signs, postmortem and microbiological findings were used to evaluate the degree of infection. Serum and bronchial lavage fluids (BAL) were collected sequentially, before contact and over a period of one year after contact. The kinetics of the different antibody isotypes to MmmSC was established. Based on the severity of the clinical signs, post mortem and microbiological findings, the animals were classified into three groups as acute form with deaths, sub-acute to chronic form and resistant animals. Seroconversion was never observed for the control animals throughout the duration of the experiment, nor for those classified as resistant. Instead, seroconversion was measured for all other cattle either with acute or sub-acute to chronic forms of the disease. For these animals, IgM, IgG1, IgG2 and IgA responses were detected in the serum and BAL samples. The kinetics of the IgM, IgG1 and IgG2 responses was nearly similar between both groups of animals. No evident correlation could thus be established between the levels of these isotypes and the severity of the disease. Levels of IgA were high in both BAL and serum samples of animals with sub-acute to chronic forms of the disease, and tended to persist throughout the entire experimental period. In contrast, animals with acute forms of the disease showed low levels of IgA in their BAL samples with none or very transient but low levels of IgA in the serum samples. Our results thus demonstrated that IgA is produced locally in MmmSC experimentally infected cattle by contact and may play a role in protection against contagious bovine pleuropneumonia.</p>
dc.description.comments <p>This article is from <em>Veterinary Resarch</em> 37 (2006): 733, doi:<a href="http://dx.doi.org/10.1051/vetres:2006032" target="_blank">10.1051/vetres:2006032</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/64/
dc.identifier.articleid 1069
dc.identifier.contextkey 7791323
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/64
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92371
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/64/2006_Roth_PulmonarySerum.pdf|||Sat Jan 15 01:21:49 UTC 2022
dc.source.uri 10.1051/vetres:2006032
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords contagious bovine pleuropneumonia
dc.subject.keywords experimental infection
dc.subject.keywords humoral response
dc.subject.keywords MmmSCspecific Ig isotypes
dc.subject.keywords protective immune mechanism
dc.title Pulmonary and Serum Antibody Responses Elicited in Zebu Cattle Experimentally Infected with Mycoplasma mycoides Subsp. mycoides SC by Contact Exposure
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 909dd0b2-ec0a-41e2-b4e0-9e5ff76b7622
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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