Hypercalcemia of malignancy associated with exocrine pancreatic adenocarcinoma in a dog

dc.contributor.author Johannes, Chad
dc.contributor.author Heinrich, Ellen
dc.contributor.author Musser, Margaret
dc.contributor.author Andreasen, Claire
dc.contributor.author Andreasen, Claire
dc.contributor.department Veterinary Pathology
dc.contributor.department Veterinary Clinical Sciences
dc.date 2021-03-09T18:56:42.000
dc.date.accessioned 2021-04-30T12:26:14Z
dc.date.available 2021-04-30T12:26:14Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.issued 2020-10-01
dc.description.abstract <p>A 10.5‐year‐old, male, neutered Samoyed was presented to the Iowa State University Lloyd Veterinary Medical Center with history (including prior surgical biopsy), non‐specific acute clinical signs and clinicopathology changes most consistent with pancreatitis. Marked hypercalcemia developed within a short span of time, raising clinical concerns for neoplasia. Diagnostic imaging and fine‐needle aspirate cytology were consistent with pancreatitis. Marked elevation in parathyroid hormone–related protein with low parathyroid hormone further supported the diagnosis of underlying neoplasia. The dog’s clinical status declined despite aggressive medical supportive therapy. Humane euthanasia was elected. Postmortem examination revealed an extensive pancreatic neoplasm confirmed as exocrine pancreatic adenocarcinoma with diffuse intra‐abdominal metastases. Acute kidney injury most likely resulted from the severe pancreatic inflammation (pancreatitis) and hypercalcemia of malignancy caused by the exocrine pancreatic adenocarcinoma. This is the first reported case of hypercalcemia of malignancy associated with exocrine pancreatic adenocarcinoma in a dog.</p>
dc.description.comments <p>This is the published version of the following article: Johannes, Chad M., Ellen RE Heinrich, Margaret L. Musser, and Claire B. Andreasen. "Hypercalcemia of malignancy associated with exocrine pancreatic adenocarcinoma in a dog." <em>Veterinary Record Case Reports</em> 8, no. 4 (2020): e001190. DOI: <a href="https://doi.org/10.1136/vetreccr-2020-001190" target="_blank">10.1136/vetreccr-2020-001190</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vpath_pubs/115/
dc.identifier.articleid 1118
dc.identifier.contextkey 22002245
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/115
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/105188
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vpath_pubs/115/2020_AndreasenClaire_HypercalcemiaMalignancy.pdf|||Fri Jan 14 18:51:55 UTC 2022
dc.source.uri 10.1136/vetreccr-2020-001190
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.keywords exocrine pancreatic adenocarcinoma
dc.subject.keywords hypercalcemia of malignancy
dc.subject.keywords paraneoplastic
dc.title Hypercalcemia of malignancy associated with exocrine pancreatic adenocarcinoma in a dog
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication 1ad68def-86ae-460b-8808-f1b1febafd0a
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