Defective function of leukocytes from cattle persistently infected with bovine viral diarrhea virus, and the influence of recombinant cytokines

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1991-03-01
Authors
Brown, Gayle
Bolin, Steve
Roth, James
Frank, Dagmar
Roth, James
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Roth, James
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Veterinary Microbiology and Preventive Medicine
Abstract

Cattle persistently infected with bovine viral diarrhea (BVD) virus have decreased neutrophil and lymphocyte functions. We reevaluated these functions and further characterized the inhibition of persistent BVD virus infection in neutrophils, using sensitive kinetic assays. In addition, the influence of in vitro incubation of neutrophils with recombinant bovine interferon gamma (~IloIFN gamma) and in vitro incubation of lymphocytes with recombinant bovine interleukin-2 was evaluated.

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This article is published as Brown, G.B., S.R. Bolin, D.E. Frank, and J.A. Roth. 1991. Defective function of leukocytes from cattle persistently infected with bovine viral diarrhea virus, and the influence of recombinant cytokines. Am J Vet Res, 52:381-387.

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