Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study.

dc.contributor.author Lang, James A.
dc.contributor.author Pitchford, Lisa M
dc.contributor.author Khoo, Paul
dc.contributor.author Angus, Hector
dc.contributor.author Lang, James
dc.contributor.author Lowry, Kristin
dc.contributor.author Ruby, Carol
dc.contributor.author Krajek, Alex C
dc.contributor.author Fuller, John C
dc.contributor.author Sharp, Rick L
dc.contributor.department Kinesiology
dc.contributor.other Kinesiology
dc.date.accessioned 2022-02-24T18:20:06Z
dc.date.available 2022-02-24T18:20:06Z
dc.date.issued 2020-10-15T00:00:00Z
dc.description.abstract The primary aim of this study was to determine whether supplementation with calcium β-hydroxy-β-methylbutyrate (HMB) and vitamin D3 (D) would enhance muscle function and strength in older adults. Older adults over 60 years of age with insufficient circulating 25-hydroxy-vitamin D (25OH-D) levels were enrolled in a double-blinded controlled 12-month study. Study participants were randomly assigned to treatments consisting of: (a) Control + no exercise, (b) HMB+D + no exercise, (c) Control + exercise, and (d) HMB+D + exercise. The study evaluated 117 participants via multiple measurements over the 12 months that included body composition, strength, functionality, and questionnaires. HMB+D had a significant benefit on lean body mass within the nonexercise group at 6 months (0.44 ± 0.27 kg, HMB+D vs -0.33 ± 0.28 kg, control, p < .05). In nonexercisers, improvement in knee extension peak torque (60°/s) was significantly greater in HMB+D-supplemented participants than in the nonsupplemented group (p = .04) at 3 months, 10.9 ± 5.7 Nm and -5.2 ± 5.9 Nm, respectively. A composite functional index, integrating changes in handgrip, Get Up, and Get Up and Go measurements, was developed. HMB+D + no exercise resulted in significant increases in the functional index compared with those observed in the control + no exercise group at 3 (p = .03), 6 (p = .04), and 12 months (p = .04). Supplementation with HMB+D did not further improve the functional index within the exercising group. This study demonstrated the potential of HMB and vitamin D3 supplementation to enhance muscle strength and physical functionality in older adults, even in individuals not engaged in an exercise training program.
dc.description.comments This article is published as John A Rathmacher, PhD, Lisa M Pitchford, PhD, Paul Khoo, BS, Hector Angus, MS, James Lang, PhD, Kristin Lowry, PT, PhD, Carol Ruby, MS, Alex C Krajek, BS, John C Fuller, Jr, PhD, Rick L Sharp, PhD, Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study, The Journals of Gerontology: Series A, Volume 75, Issue 11, November 2020, Pages 2089–2097, https://doi.org/10.1093/gerona/glaa218. © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.identifier.issn 1079-5006
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/avVOlgmr
dc.language.iso en
dc.publisher Published by Oxford University Press on behalf of The Gerontological Society of America.
dc.source.uri https://doi.org/10.1093/gerona/glaa218 *
dc.subject β-Hydroxy-β-methylbutyrate
dc.title Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study.
dc.type Article
dspace.entity.type Publication
relation.isAuthorOfPublication cf2c294d-7d62-42c4-8e4d-5a934603e1aa
relation.isOrgUnitOfPublication f7b0f2ca-8e43-4084-8a10-75f62e5199dd
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