Shiga Toxin-Producing Escherichia coli Infection: Temporal and Quantitative Relationships among Colonization, Toxin Production, and Systemic Disease

dc.contributor.author Cornick, Nancy
dc.contributor.author Matise, Ilze
dc.contributor.author Cornick, Nancy
dc.contributor.author Samuel, James
dc.contributor.author Bosworth, Brad
dc.contributor.author Moon, Harley
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-17T09:56:31.000
dc.date.accessioned 2020-07-07T05:14:17Z
dc.date.available 2020-07-07T05:14:17Z
dc.date.issued 2000-01-01
dc.description.abstract <p>Edema disease, a naturally occurring disease of swine caused by Shiga toxin-producing <em>Escherichia coli</em> (STEC), was used as a model for the sequence of events that occur in the pathogenesis of STEC infection. The mean time from production of levels of Shiga toxin 2e (Stx2e) detectable in the feces (day 1) to the onset of clinical disease (neurologic disturbances or death) was 5 days (range, 3–9). Bacterial colonization and titers of Stx2e in the ileum peaked at 4 days after inoculation in pigs without signs of clinical disease and at 6 days after inoculation in clinically affected pigs. Animals with the greatest risk of progressing to clinical disease tended to have the highest fecal toxin titers (⩾1 : 4096). Stx2e was detected in the red cell fraction from blood of some pigs showing clinical signs of edema disease but was not detected in the serum or cerebrospinal fluid.</p>
dc.description.comments <p>This article is from <em>Journal of Infectious Diseases</em> 181 (2000): 242, doi:<a href="http://dx.doi.org/10.1086/315172" target="_blank">10.1086/315172</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/100/
dc.identifier.articleid 1101
dc.identifier.contextkey 7983261
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/100
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92201
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/100/2000_Cornick_ShigaToxinProducing.pdf|||Fri Jan 14 18:11:35 UTC 2022
dc.source.uri 10.1086/315172
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Toxicology and Pharmacology
dc.title Shiga Toxin-Producing Escherichia coli Infection: Temporal and Quantitative Relationships among Colonization, Toxin Production, and Systemic Disease
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication a89b8fad-4329-4bb1-bbcd-c1d3b324f0f7
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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