Pharmacokinetics of fentanyl citrate and norfentanyl in Holstein calves and effect of analytical performances on fentanyl parameter estimation

dc.contributor.author Smith, Joe
dc.contributor.author Smith, Joe
dc.contributor.author Coetzee, Johann
dc.contributor.author Fisher, Isaac
dc.contributor.author Mochel, Jonathan
dc.contributor.author Borts, David
dc.contributor.author Mochel, Jonathan
dc.contributor.department Biomedical Sciences
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2019-05-05T19:33:28.000
dc.date.accessioned 2020-07-07T05:12:47Z
dc.date.available 2020-07-07T05:12:47Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2018
dc.date.embargo 2019-03-30
dc.date.issued 2018-08-01
dc.description.abstract <p>This study describes the pharmacokinetics of intravenously administered (i.v.) fentanyl citrate, and its primary metabolite norfentanyl in Holstein calves. Eight calves (58.6 ± 2.2 kg), aged 3–4 weeks, were administered fentanyl citrate at a single dose of 5.0 μg/kg i.v. Blood samples were collected from 0 to 24 hr. Plasma (nor)fentanyl concentrations were determined using liquid chromatography with mass spectrometry and a lower limit of quantification (LLOQ) of 0.03 ng/ml. To explore the effect of analytical performance on fentanyl parameter estimation, the noncompartmental pharmacokinetic analysis was then repeated with a hypothetical LLOQ value of 0.05 ng/ml. Terminal elimination half‐life was estimated at 12.7 and 3.6 hr for fentanyl and norfentanyl, respectively. For fentanyl, systemic clearance was estimated at 2.0 L hr−1 kg−1, volume of distribution at steady‐state was 24.8 L/kg and extraction ratio was 0.42. At a hypothetical LLOQ of 0.05 ng/ml fentanyl half‐life, volume of distribution at steady‐state and clearance were, respectively, of 3.0 hr, 8.8 L/kg and 3.4 L kg−1 hr−1. Fentanyl citrate administered i.v. at 5.0 μg/kg can reach levels associated with analgesia in other species. Pharmacokinetic parameters should be interpreted with respect to LLOQ, as lower limits can influence estimated parameters, such as elimination half‐life or systemic clearance and have significant impact on dosage regimen selection in clinical practice.</p>
dc.description.comments <p>This is the pre-peer reviewed version of the following article: Smith, J. S., J. F. Coetzee, I. W. G. Fisher, D. J. Borts, and J. P. Mochel. "Pharmacokinetics of fentanyl citrate and norfentanyl in Holstein calves and effect of analytical performances on fentanyl parameter estimation." <em>Journal of Veterinary Pharmacology and Therapeutics</em> 41, no. 4 (2018): 555-561, which has been published in final form at DOI: <a href="http://dx.doi.org/10.1111/jvp.12501" target="_blank">10.1111/jvp.12501</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vdpam_pubs/130/
dc.identifier.articleid 1133
dc.identifier.contextkey 14087357
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vdpam_pubs/130
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91973
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_pubs/130/2018_SmithJoseph_PharmacokineticsFentanyl.pdf|||Fri Jan 14 19:42:06 UTC 2022
dc.source.uri 10.1111/jvp.12501
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Toxicology and Pharmacology
dc.subject.keywords Fentanyl
dc.subject.keywords Cattle
dc.subject.keywords Calves
dc.subject.keywords Norfentanyl
dc.title Pharmacokinetics of fentanyl citrate and norfentanyl in Holstein calves and effect of analytical performances on fentanyl parameter estimation
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 0959860b-5308-482e-89f6-3e6882344a3b
relation.isAuthorOfPublication a34180b7-6b71-4b6f-a08d-5a53c5122d9b
relation.isOrgUnitOfPublication 184db3f2-d93f-4571-8ad7-07c8a9e6a5c9
relation.isOrgUnitOfPublication 5ab07352-4171-4f53-bbd7-ac5d616f7aa8
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