Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection

dc.contributor.author Wurtele, Eve
dc.contributor.author Guarnieri, Joseph W.
dc.contributor.author Saravia-Butler, Amanda
dc.contributor.author Singh, Urminder
dc.contributor.author Wurtele, Eve Syrkin
dc.contributor.author Beheshti, Afshin
dc.contributor.author Wallace, Douglas C.
dc.contributor.author et al.
dc.contributor.department Genetics, Development and Cell Biology
dc.date.accessioned 2022-03-03T19:19:23Z
dc.date.available 2022-03-03T19:19:23Z
dc.date.issued 2022-02-22
dc.description.abstract Defects in mitochondrial oxidative phosphorylation (OXPHOS) have been reported in COVID-19 patients, but the timing and organs affected vary among reports. Here, we reveal the dynamics of COVID-19 through transcription profiles in nasopharyngeal and autopsy samples from patients and infected rodent models. While mitochondrial bioenergetics is repressed in the viral nasopharyngeal portal of entry, it is up regulated in autopsy lung tissues from deceased patients. In most disease stages and organs, discrete OXPHOS functions are blocked by the virus, and this is countered by the host broadly up regulating unblocked OXPHOS functions. No such rebound is seen in autopsy heart, results in severe repression of genes across all OXPHOS modules. Hence, targeted enhancement of mitochondrial gene expression may mitigate the pathogenesis of COVID-19.
dc.description.comments This preprint is made available through bioRxiv at doi:10.1101/2022.02.19.481089. Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/7wbO2Yyv
dc.language.iso en
dc.source.uri https://doi.org/10.1101/2022.02.19.481089 *
dc.title Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection
dc.type Preprint
dspace.entity.type Publication
relation.isAuthorOfPublication a7de6326-d86c-4395-b9e6-51187c7f1782
relation.isOrgUnitOfPublication 7bab215d-4571-4c33-867c-28881af20485
File
Original bundle
Now showing 1 - 1 of 1
Name:
2022-Wurtele-TargetedDownPreprint.pdf
Size:
15.1 MB
Format:
Adobe Portable Document Format
Description:
Collections