Gene expression analysis during retinal ganglion cell development

dc.contributor.author Wester, Andrea
dc.contributor.department Genetics, Development and Cell Biology
dc.date 2018-02-17T00:13:50.000
dc.date.accessioned 2020-07-07T05:11:08Z
dc.date.available 2020-07-07T05:11:08Z
dc.date.issued 2015-04-14
dc.description.abstract <p>Retinal ganglion cells are the final output neurons that gather electrical signals from light-sensing cells and relay this information to discrete locations in the brain. The loss of ganglion cells due to cell death is an irreversible process in glaucoma. Therefore, to fully restore vision in glaucoma patients, cellular replacement therapy is being explored as future treatment. However, for cellular replacement therapy to be a viable option, we must gain a better understanding of the networks of genes that combine together to generate retinal ganglion cells. The goal of our lab is to gain insight into the gene networks responsible for the generation of retinal ganglion cells. Using single-cell transcriptomics and microarrays, we have characterized the transcriptional programs that are activated in individual developing ganglion cells during normal development in the mouse, zebrafish and chicken. These experiments enable us to focus our future functional experiments on those networks that are the most conserved and, therefore, the most likely to be critical in ganglion cell development.</p>
dc.identifier archive/lib.dr.iastate.edu/undergradresearch_symposium/2015/presentations/34/
dc.identifier.articleid 1122
dc.identifier.contextkey 7558443
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath undergradresearch_symposium/2015/presentations/34
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91697
dc.relation.ispartofseries Symposium on Undergraduate Research and Creative Expression
dc.source.bitstream archive/lib.dr.iastate.edu/undergradresearch_symposium/2015/presentations/34/4.B.1_20Wester.pdf|||Fri Jan 14 23:40:44 UTC 2022
dc.subject.disciplines Developmental Biology
dc.subject.disciplines Genetics
dc.title Gene expression analysis during retinal ganglion cell development
dc.type event
dc.type.genre article
dspace.entity.type Publication
relation.isOrgUnitOfPublication 9e603b30-6443-4b8e-aff5-57de4a7e4cb2
relation.isSeriesOfPublication 6730f354-97b8-4408-bad3-7e5c3b2fca9d
thesis.degree.discipline Biology
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