A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy

dc.contributor.author Marsh, Thomas
dc.contributor.author Vesenka, James
dc.contributor.author Henderson, Eric
dc.contributor.author Henderson, Eric
dc.contributor.department Zoology and Genetics
dc.date 2018-02-18T10:06:06.000
dc.date.accessioned 2020-07-07T05:16:54Z
dc.date.available 2020-07-07T05:16:54Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 1995
dc.date.issued 1995
dc.description.abstract <p>G-DNA is a polymorphic family of quadruple helical nucleic acid structures containing guanine tetrad motifs [G-quartets; Willlamson, J. R., Raghuraman.M.K. and CechJ.R. (1989) <em>Cell</em> 59, 871–880; Williamson. J. R. (1993) <em>Proc. Natl. Acad. Scl</em> . USA 90, 3124–3124]. Guanine rich oligonucleotides that are self-complimentary, as found in many telomeric G-strand repeat sequences, form G-DNA in the presence of mono-valent and/or divalent metal cations. In this report we use the atomic force microscope (AFM) to explore the structural characteristics of long, linear polymers formed by the telomeric oligonucleotide d(GGGG TTGGGG) in the presence of specific metal cations. In the AFM these polymers, termed G-wires, appear as filaments whose height and length are determined by the metal ions present during the self-assembly process. The highly ordered, controllable serf-assembly of G-wires could provide a basis for developing advanced blomaterials.</p>
dc.description.comments <p>This article is from <em>Nucleic Acids Research </em>23 (1995): 696, doi: <a href="https://doi.org/10.1093/nar/23.4.696">10.1093/nar/23.4.696</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/zool_pubs/34/
dc.identifier.articleid 1036
dc.identifier.contextkey 10137219
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath zool_pubs/34
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92644
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/zool_pubs/34/1995_Henderson_NewDNA.pdf|||Fri Jan 14 23:41:02 UTC 2022
dc.source.uri 10.1093/nar/23.4.696
dc.subject.disciplines Cell and Developmental Biology
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Zoology
dc.title A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 68bc511a-afd6-4353-ae20-066de33682b9
relation.isOrgUnitOfPublication 4a2929da-5374-4338-b62f-f5fd9e156ef9
Original bundle
Now showing 1 - 1 of 1
4.53 MB
Adobe Portable Document Format