A Clinical Index for Disease Activity in Cats with Chronic Enteropathy

dc.contributor.author Wang, Chong
dc.contributor.author Jergens, Albert
dc.contributor.author Crandell, J. M.
dc.contributor.author Evans, R.
dc.contributor.author Ackermann, Mark
dc.contributor.author Miles, Kristina
dc.contributor.author Wang, Chong
dc.contributor.author Ackermann, Mark
dc.contributor.department Veterinary Pathology
dc.contributor.department Veterinary Clinical Sciences
dc.contributor.department Statistics
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2018-02-17T17:46:46.000
dc.date.accessioned 2020-07-07T05:13:34Z
dc.date.available 2020-07-07T05:13:34Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 2010
dc.date.issued 2010-01-01
dc.description.abstract <p><strong>Background: </strong>There is a need for a clinically useful, quantitative index for measurement of disease activity in cats with chronic enteropathy (CE).</p> <p><strong>Objective: </strong>To develop a numerical activity index that is of practical value to clinicians treating CE in cats.</p> <p><strong>Animals: </strong>Eighty-two cats with CE.</p> <p><strong>Methods: </strong>Retrospective case review of 59 cats diagnosed with inflammatory bowel disease (IBD). Prospective validation study of 23 cats having either IBD or food-responsive enteropathy (FRE). Multivariate regression analysis was used to identify which combination of clinical and laboratory variables were best associated with intestinal inflammation of IBD. This combination of variables was expressed in a score that was used as an activity index for the prospective assessment of disease activity and of the effect of treatment in cats with IBD or FRE.</p> <p><strong>Results: </strong>The combination of gastrointestinal signs, endoscopic abnormalities, serum total protein, serum alanine transaminase/alkaline phosphatase activity, and serum phosphorous concentration had the best correlation with histopathologic inflammation and comprise the feline chronic enteropathy activity index (FCEAI). Positive treatment responses in cats with CE were accompanied by significant (<em>P</em> < .05) reductions in FCEAI scores after treatment.</p> <p><strong>Conclusions and Clinical Importance: </strong>The FCEAI is a simple numerical measure of inflammatory activity in cats with CE. The scoring index can be reliably used in the initial assessment of disease severity for both IBD and FRE and as a measure of clinical response to treatment for these disorders.</p>
dc.description.comments <p>This article is from <em>Journal of Veterinary Internal Medicine </em>24 (2010); 1027, doi: <a href="http://dx.doi.org/10.1111/j.1939-1676.2010.0549.x" target="_blank">10.1111/j.1939-1676.2010.0549.x</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vdpam_pubs/67/
dc.identifier.articleid 1065
dc.identifier.contextkey 8694553
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vdpam_pubs/67
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92095
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_pubs/67/2010_Wang_ClinicalIndex.pdf|||Sat Jan 15 01:27:08 UTC 2022
dc.source.uri 10.1111/j.1939-1676.2010.0549.x
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Statistical Methodology
dc.subject.disciplines Veterinary Anatomy
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.disciplines Veterinary Physiology
dc.subject.keywords Clinical scoring
dc.subject.keywords FCEAI
dc.subject.keywords Feline chronic enteropathy activity index
dc.subject.keywords Food-responsive enteropathy
dc.subject.keywords Inflammatory bowel disease
dc.title A Clinical Index for Disease Activity in Cats with Chronic Enteropathy
dc.type article
dc.type.genre article
dspace.entity.type Publication
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