Role of the DksA-Like Protein in the Pathogenesis and Diverse Metabolic Activity of Campylobacter jejuni

dc.contributor.author Plummer, Paul
dc.contributor.author Yun, Jiae
dc.contributor.author Jeon, Byeonghwa
dc.contributor.author Zhang, Qijing
dc.contributor.author Barton, Yi-Wen
dc.contributor.author Plummer, Paul
dc.contributor.author Zhang, Qijing
dc.contributor.author Ryu, Sangryeol
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-17T10:19:41.000
dc.date.accessioned 2020-07-07T05:14:25Z
dc.date.available 2020-07-07T05:14:25Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2008
dc.date.issued 2008-07-01
dc.description.abstract <p>DksA is well known for its regulatory role in the transcription of rRNA and genes involved in amino acid synthesis in many bacteria. DksA has also been reported to control expression of virulence genes in pathogenic bacteria. Here, we elucidated the roles of a DksA-like protein (CJJ81176_0160, Cj0125c) in the pathogenesis of<em>Campylobacter jejuni</em>. As in other bacteria, transcription of stable RNA was repressed by the DksA-like protein under stress conditions in <em>C. jejuni</em>. Transcriptomic and proteomic analyses of <em>C. jejuni</em> 81-176 and an isogenic mutant lacking the DksA-like protein showed differential expression of many genes involved in amino acid metabolism, iron-related metabolism, and other metabolic reactions. Also, the <em>C. jejuni</em> DksA-like protein mutant exhibited a decreased ability to invade intestinal cells and induce release of interleukin-8 from intestinal cells. These results suggest that the DksA-like protein plays an important regulatory role in diverse metabolic events and the virulence of <em>C. jejuni</em>.</p>
dc.description.comments <p>This article is from <em>Journal of Bacteriology</em> 190 (2008): 4512, doi:<a href="http://dx.doi.org/10.1128/JB.00105-08" target="_blank">10.1128/JB.00105-08</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/121/
dc.identifier.articleid 1118
dc.identifier.contextkey 7989665
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/121
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92223
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/121/2008_Plummer_RoleDksALike.pdf|||Fri Jan 14 19:12:47 UTC 2022
dc.source.uri 10.1128/JB.00105-08
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.title Role of the DksA-Like Protein in the Pathogenesis and Diverse Metabolic Activity of Campylobacter jejuni
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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