Cytotoxic and Antigenotoxic Activities of Phosvitin From Egg Yolk

dc.contributor.author Hoon, Sunhee
dc.contributor.author Ahn, Dong
dc.date 2018-08-25T21:41:27.000
dc.date.accessioned 2020-06-29T23:36:40Z
dc.date.available 2020-06-29T23:36:40Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 2016
dc.date.embargo 2016-02-17
dc.date.issued 2016-01-01
dc.description.abstract <p>Egg yolk phosvitin is one of the most phosphorylated proteins in nature, and thus has a strong metal-binding ability. The objective of this study was to evaluate the cytotoxic and antigenotoxic activities of phosvitin in vitro. Using the MTT assay, the cytotoxicity of phosvitin was evaluated in human cancer cell lines of various tissue origins, including the cervix (HeLa), breast (MCF-7), stomach (AGS), lung (A549 and SK-MES-1), liver (HepG2), and larynx (Hep-2). The growth of all cancer cell lines was inhibited in a dose-dependent manner by phosvitin. Among the cancer cell lines tested, MCF-7 and SK-MES-1 were the least sensitive and HeLa, AGS, and HepG2 were the most sensitive to phosvitin. The IC50 values of phosvitin were 5.38, 11.57, 4.78, 6.98, 11.82, 3.93, and 9.97 mg/mL for HeLa, MCF-7, AGS, A549, SK-MES-1, HepG2, and Hep-2, respectively. The protective effects of phosvitin against DNA damage in human leukocytes indicated that phosvitin showed protective effects against the oxidative stress-induced DNA damages in human leukocytes. These results suggested that phosvitin has a high potential to be used as an anticancer agent for humans.</p>
dc.identifier archive/lib.dr.iastate.edu/ans_air/vol662/iss1/64/
dc.identifier.articleid 2215
dc.identifier.contextkey 8163821
dc.identifier.doi https://doi.org/10.31274/ans_air-180814-233
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_air/vol662/iss1/64
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9278
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.relation.ispartofseries ASL R3103
dc.source.bitstream archive/lib.dr.iastate.edu/ans_air/vol662/iss1/64/R3103.pdf|||Sat Jan 15 01:21:52 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Poultry or Avian Science
dc.title Cytotoxic and Antigenotoxic Activities of Phosvitin From Egg Yolk
dc.type article
dc.type.genre poultry
dspace.entity.type Publication
relation.isAuthorOfPublication d3386101-2f0d-4375-ab44-ac1addb6a9ad
relation.isJournalIssueOfPublication c408461a-f35a-449e-8927-ff468de09153
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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