The prepubertal ontogeny of neuropeptides in the male Meishan pig brain

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1996
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Pearson, Paul
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Carol D. Jacobson
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Genetics, Development and Cell Biology

The Department of Genetics, Development, and Cell Biology seeks to teach subcellular and cellular processes, genome dynamics, cell structure and function, and molecular mechanisms of development, in so doing offering a Major in Biology and a Major in Genetics.

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The Department of Genetics, Development, and Cell Biology was founded in 2005.

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This dissertation describes the immunohistochemical localization of three neuropeptides in the brain of the male Meishan pig throughout prenatal and prepubertal development;The first study details the ontogeny of neuropeptide Y (NPY) in the male Meishan pig brain. Neuropeptide Y-like immunoreactivity (NPY-IR) was seen in cell bodies and fibers throughout the brain from gestational day (g)30 through postnatal day (pn)50. Cell bodies and fibers containing NPY-IR generally increase in number and distribution in the brain prenatally. However, immunoreactive cell bodies decline in the early postnatal period, especially in the arcuate nucleus of the hypothalamus. This may indicate a functional maturation of food intake control pathways;The second study describes the prepubertal ontogeny of galanin-like immunoreactivity (GAL-IR). Galanin-IR in cell bodies and fibers was evident in the brain at all ages, especially in the hypothalamus. Throughout prenatal development cell bodies and fibers containing GAL-IR generally increased in number and distribution in the brain showing a pattern by pn1 that was consistent through postnatal ages;The third study investigated the prepubertal ontogeny of luteinizing hormone-releasing hormone-like immunoreactivity (LHRH-IR) in the telencephalon and diencephalon. Luteinizing hormone-releasing hormone-IR in cell bodies and fibers was detected at g30 entering the brain along the terminal nerve and in the basal telencephalon. The number of immunoreactive cells increased and immunoreactive fibers were present in the median eminence at g50. Further increases were seen prenatally, but changed little postnatally. These results confirm the olfactory origin of LHRH cells in the pig and suggest a breed difference in the ontogeny of reproductive control systems in the pig;The temporal and neuroanatomical relationship of these peptides suggest that they play important roles in the control of food intake, growth and reproduction in the Meishan pig, a Chinese breed known for its superior reproductive characteristics but slow growth and obesity. Future studies will investigate the interrelationships of these peptides with respect to the control of gonadotropic and somatotropic processes in the pig.

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Mon Jan 01 00:00:00 UTC 1996