Polymer-based delivery systems for support and delivery of bacteriophages

dc.contributor.advisor Rebecca Cademartiri
dc.contributor.advisor Kaitlin Bratlie
dc.contributor.author Brown, Alyssa
dc.contributor.department Materials Science and Engineering
dc.date 2018-08-11T13:05:46.000
dc.date.accessioned 2020-06-30T02:52:39Z
dc.date.available 2020-06-30T02:52:39Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2014
dc.date.embargo 2001-01-01
dc.date.issued 2014-01-01
dc.description.abstract <p>One of the most urgent problems in the fields of medicine and agriculture is the decreasing effectiveness of antibiotics. Once a miracle drug, antibiotics have recently become associated with the creation of antibiotic-resistant bacteria. The main limitations of these</p> <p>treatments include lack of both adaptability and specificity. To overcome these shortcomings of current antibiotic treatments, there has been a renewed interest in bacteriophage research.</p> <p>Bacteriophages are naturally-occurring viruses that lyse bacteria. They are highly specific, with each bacteriophage type lysing a narrow range of bacteria strains. Bacteriophages are also ubiquitous biological entities, populating environments where bacterial growth is supported. Just as humans are exposed to bacteria in their daily lives, we are exposed to bacteriophages as well.</p> <p>To use bacteriophages in practical applications, they must be delivered to the site of an infection in a controlled-release system. Two systems were studied to observe their support of bacteriophage lytic activity, as well as investigate the possibility of controlling bacteriophage release rates. First, hydrogels were studied, using crosslinking and blending techniques to achieve a range of release profiles. Second, polyanhydride microparticles were studied, evaluating release rates as a function of monomer chemistries.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/etd/13859/
dc.identifier.articleid 4866
dc.identifier.contextkey 5777571
dc.identifier.doi https://doi.org/10.31274/etd-180810-2525
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath etd/13859
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/28046
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/etd/13859/Brown_iastate_0097M_14277.pdf|||Fri Jan 14 20:02:37 UTC 2022
dc.subject.disciplines Biomedical
dc.subject.disciplines Mechanics of Materials
dc.subject.disciplines Microbiology
dc.subject.keywords Bacteriophage
dc.subject.keywords Drug Delivery
dc.subject.keywords Hydrogel
dc.subject.keywords Microparticle
dc.subject.keywords Polyanhydride
dc.title Polymer-based delivery systems for support and delivery of bacteriophages
dc.type article
dc.type.genre thesis
dspace.entity.type Publication
relation.isOrgUnitOfPublication bf9f7e3e-25bd-44d3-b49c-ed98372dee5e
thesis.degree.level thesis
thesis.degree.name Master of Science
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