The Current Understanding of Minimal Change Disease and Available Treatments: A Literature Review

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2022-05
Authors
Grogan, Shayna
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Kimber, Michael
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Kimber, Michael
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Abstract
Minimal change disease (MCD) is a nonspecific nephrotic syndrome accounting for up to 90% of nephrotic syndrome in children and 15% in adults. The pathogenesis of the disease remains unclear; however, there are several hypotheses suggesting an immune system abnormality. Clinically, the disease presentation varies greatly, especially between children and adults. The method of diagnosis is currently limited to examination by renal biopsy, but there is potential for the use of protein biomarkers to aid in diagnosis. Guidelines for treatment are vague but typically consist of corticosteroid therapy as the primary method. This paper aims to identify the current understanding of MCD and the current clinical practices and available treatments. There has been significant progress in understanding the pathogenesis and alternative treatment options for those who do not respond well to corticosteroids; however, much more research is needed for MCD, especially in adults.
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May 2022