Methylation of the oxytocin receptor gene mediates the effect of adversity on negative schemas and depression

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2017-08-01
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Simons, Ronald
Lei, Man Kit
Beach, Steven
Philibert, Robert
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Cutrona, Carolyn
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Psychology
The Department of Psychology may prepare students with a liberal study, or for work in academia or professional education for law or health-services. Graduates will be able to apply the scientific method to human behavior and mental processes, as well as have ample knowledge of psychological theory and method.
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Building upon various lines of research, we posited that methylation of the oxytocin receptor gene (OXTR) would mediate the effect of adult adversity on increased commitment to negative schemas and in turn the development of depression. We tested our model using structural equation modeling and longitudinal data from a sample of 100 middle-aged, African American women. The results provided strong support for the model. Analysis of the 12 CpG sites available for the promoter region of the OXTR gene identified four factors. One of these factors was related to the study variables, whereas the others were not. This factor mediated the effect of adult adversity on schemas relating to pessimism and distrust, and these schemas, in turn, mediated the impact of OXTR methylation on depression. All indirect effects were statistically significant, and they remained significant after controlling for childhood trauma, age, romantic relationship status, individual differences in cell types, and average level of genome-wide methylation. These finding suggest that epigenetic regulation of the oxytocin system may be a mechanism whereby the negative cognitions central to depression become biologically embedded.

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This is a manuscript of an article published as Simons, Ronald L., Man Kit Lei, Steven RH Beach, Carolyn E. Cutrona, and Robert A. Philibert. "Methylation of the oxytocin receptor gene mediates the effect of adversity on negative schemas and depression." Development and psychopathology 29, no. 3 (2017): 725-736. doi: 10.1017/S0954579416000420. Posted with permission.

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Fri Jan 01 00:00:00 UTC 2016
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