Controlled Release from Cleavable Polymerized Liposomes upon Redox and pH Stimulation

dc.contributor.author Zhang, Shiyong
dc.contributor.author Zhao, Yan
dc.contributor.department Chemistry
dc.date 2018-02-17T06:50:29.000
dc.date.accessioned 2020-06-30T01:18:09Z
dc.date.available 2020-06-30T01:18:09Z
dc.date.copyright Sat Jan 01 00:00:00 UTC 2011
dc.date.issued 2011-03-01
dc.description.abstract <p>A gallate derivative with three propargyl groups was coupled to palmitoyl oleoyl phosphoethanolamine (POPE). The resulting anionic lipid was formulated with common lipids such as palmitoyl oleoyl phosphatidyl choline (POPC) to form large unilamellar vesicles (LUVs). Polymerization of the LUVs was accomplished by the Cu(I)-catalyzed click reaction between the propargyl groups and the azide groups in the cross-linker. When the cross-linker contained a disulfide or ketal group, the resulting polymerized liposomes depolymerized and released entrapped contents upon the addition of a reducing thiol or under weakly acidic conditions. The click reaction allowed simultaneous multivalent surface functionalization during cross-linking, making these cleavable polymerized liposomes (CPLs) potentially very useful in the delivery and controlled release of pharmaceutical agents.</p>
dc.description.comments <p>Reprinted (adapted) with permission from <em>Bioconjugate Chemistry</em> 22 (2011): 523, doi:<a href="http://dx.doi.org/10.1021/bc1003197" target="_blank">10.1021/bc1003197</a>. Copyright 2011 American Chemical Society.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/chem_pubs/174/
dc.identifier.articleid 1180
dc.identifier.contextkey 7886981
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath chem_pubs/174
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/14611
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/174/0-L_2011_Zhao_ControlledRelease.pdf|||Fri Jan 14 21:22:05 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/174/2011_Zhao_ControlledRelease.pdf|||Fri Jan 14 21:22:06 UTC 2022
dc.source.uri 10.1021/bc1003197
dc.subject.disciplines Chemistry
dc.title Controlled Release from Cleavable Polymerized Liposomes upon Redox and pH Stimulation
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 82f430d1-77c0-43c2-8bd5-52f3787cc4ba
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
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