Pot-in-pot reactions: a simple and green approach to efficient organic synthesis

dc.contributor.author Atkinson, M.
dc.contributor.author Oyola-Reynoso, Stephanie
dc.contributor.author Luna, R.
dc.contributor.author Bwambok, D.
dc.contributor.author Thuo, Martin
dc.contributor.department Materials Science and Engineering
dc.date 2018-02-18T18:50:54.000
dc.date.accessioned 2020-06-30T06:07:31Z
dc.date.available 2020-06-30T06:07:31Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2015
dc.date.issued 2015-01-01
dc.description.abstract <p>Incompatible organic reactions impede efficient green synthesis by making multi-component or cascade reactions a big challenge. This review highlights pot-in-pot reactions (multiple reactions carried out in one pot by separating key reactions with a thin polymeric membrane) as an efficient, green synthetic alternative to conventional synthesis. We discuss the advantages of homogeneous processes to develop new cascade reaction sequences by reviewing the use of polymeric thimbles as selective semi-permeable walls. These thimbles allow small organic molecules to diffuse through while retaining polar reagents, polar solvents, and/or organometallic catalysts. The dynamic and versatile nature of this technique is demonstrated by performing 2- and 3-step cascade reactions in one glass pot. A pot-in-pot reaction approach to synthesis circumvents the need to isolate intermediates, or handling of toxic/unpleasant by-products, therefore enabling synthesis of otherwise challenging molecules, improving the efficiency, or enabling greener approaches to modular synthesis.</p>
dc.description.comments <p>This article is published as Atkinson, M. B. J., S. Oyola-Reynoso, R. E. Luna, D. K. Bwambok, and M. M. Thuo. "Pot-in-pot reactions: a simple and green approach to efficient organic synthesis." <em>RSC Advances</em> 5, no. 1 (2015): 597-607, doi:<a href="http://dx.doi.org/10.1039/C4RA13506G" target="_blank">10.1039/C4RA13506G</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/mse_pubs/229/
dc.identifier.articleid 1241
dc.identifier.contextkey 10539325
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath mse_pubs/229
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/55561
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/mse_pubs/229/2015_Thuo_PotPot.pdf|||Fri Jan 14 22:44:55 UTC 2022
dc.source.uri 10.1039/C4RA13506G
dc.subject.disciplines Biochemical and Biomolecular Engineering
dc.subject.disciplines Chemical Engineering
dc.subject.disciplines Materials Science and Engineering
dc.subject.disciplines Membrane Science
dc.subject.disciplines Polymer and Organic Materials
dc.title Pot-in-pot reactions: a simple and green approach to efficient organic synthesis
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication bf9f7e3e-25bd-44d3-b49c-ed98372dee5e
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