Methods for assessing cell-mediated immunity in infectious disease resistance and in the development of vaccines

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dc.contributor.author Coe Clough, Nancy
dc.contributor.author Roth, James
dc.contributor.author Roth, James
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-05-24T04:50:16.000
dc.date.accessioned 2020-07-07T05:14:59Z
dc.date.available 2020-07-07T05:14:59Z
dc.date.issued 1995-04-15
dc.description.abstract <p>Immunologic evaluation of vaccines has depended largely on the measurement of an antibody response in the serum of recipient animals. This approach, which worked well for diseases prevented in large part by humoral immunity, ignored the contributions cell-mediated immunity (CMI) or mucosal immunity make to providing protection against many infectious diseases. As a result of this approach, certain vaccines were marketed that produced a satisfactory antibody response but failed to protect vaccinates in the field from disease. In the modem biologics industry, there is increasing pressure for vaccine improvements and new technologic advancements to be based on a sound understanding of the entire basis for immunity, including cell-mediated, mucosal, and humoral immunity that develops after exposure to infectious disease agents.</p>
dc.description.comments <p>This article is published as Coe-Clough, N.E. and J.A. Roth. 1995. Methods for assessing cell-mediated immunity in infectious disease resistance and in the development of vaccines. J Am Vet Med Assoc, 206:1208-1216.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/203/
dc.identifier.articleid 1201
dc.identifier.contextkey 12142589
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/203
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92314
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/203/1995_Roth_MethodsAssessing001.PDF|||Fri Jan 14 22:23:06 UTC 2022
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Methods for assessing cell-mediated immunity in infectious disease resistance and in the development of vaccines
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 909dd0b2-ec0a-41e2-b4e0-9e5ff76b7622
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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