Large-scale association study for structural soundness and leg locomotion traits in the pig

dc.contributor.author Fan, Bin
dc.contributor.author Onteru, Suneel
dc.contributor.author Mote, Benny
dc.contributor.author Serenius, Timo
dc.contributor.author Stalder, Kenneth
dc.contributor.author Rothschild, Max
dc.contributor.department Animal Science
dc.date 2018-02-17T11:53:47.000
dc.date.accessioned 2020-06-29T23:39:18Z
dc.date.available 2020-06-29T23:39:18Z
dc.date.copyright Thu Jan 01 00:00:00 UTC 2009
dc.date.issued 2009-01-01
dc.description.abstract <p>Background: Identification and culling of replacement gilts with poor skeletal conformation and feet and leg (FL) unsoundness is an approach used to reduce sow culling and mortality rates in breeding stock. Few candidate genes related to soundness traits have been identified in the pig. Methods: In this study, 2066 commercial females were scored for 17 traits describing body conformation and FL structure, and were used for association analyses. Genotyping of 121 SNPs derived from 95 genes was implemented using Sequenom's MassARRAY system. Results: Based on the association results from single trait and principal components using mixed linear model analyses and false discovery rate testing, it was observed that APOE, BMP8, CALCR, COL1A2, COL9A1, DKFZ, FBN1 and VDBP were very highly significantly (P < 0.001) associated with body conformation traits. The genes ALOX5, BMP8, CALCR, OPG, OXTR and WNT16 were very highly significantly (P < 0.001) associated with FL structures, and APOE, CALCR, COL1A2, GNRHR, IHH, MTHFR and WNT16 were highly significantly (P < 0.01) associated with overall leg action. Strong linkage disequilibrium between CALCR and COL1A2 on SSC9 was detected, and haplotype - ACGACC- was highly significantly (P < 0.01) associated with overall leg action and several important FL soundness traits. Conclusion: The present findings provide a comprehensive list of candidate genes for further use in fine mapping and biological functional analyses.</p>
dc.description.comments <p>This is an article from <em>Genetics Selection Evolution</em> 41 (2009): 1, doi:<a href="http://dx.doi.org/10.1186/1297-9686-41-14" target="_blank">10.1186/1297-9686-41-14</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ans_pubs/246/
dc.identifier.articleid 1245
dc.identifier.contextkey 8082648
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_pubs/246
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9654
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ans_pubs/246/2009_Rothschild_LargeScaleAssociation.pdf|||Fri Jan 14 22:54:12 UTC 2022
dc.source.uri 10.1186/1297-9686-41-14
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Genetics and Genomics
dc.title Large-scale association study for structural soundness and leg locomotion traits in the pig
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 0b0a34a3-f123-4f94-a9cf-e730cb2183a6
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
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