Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies

Date
2022
Authors
Liu, Luman
Kshirsagar, Prakash G.
Gautam, Shailendra K.
Gulati, Mansi
Wafa, Emad I.
Christiansen, John C.
White, Brianna M.
Wannemuehler, Michael J.
Kumar, Sushil
Solheim, Joyce
Batra, Surinder K.
Salem, Aliasger K.
Jain, Maneesh
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Ivyspring International Publisher
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Neuroscience
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Ames Laboratory
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Chemical and Biological EngineeringMaterials Science and EngineeringNeuroscienceAmes Laboratory
Abstract
Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and biochemical stresses that lead to increased interstitial fluid pressure, vascular compression, and hypoxia. Immunotherapy-based approaches, including therapeutic vaccines, immune checkpoint inhibition, CAR-T cell therapy, and adoptive T cell therapies, are challenged by an immunosuppressive tumor microenvironment. Together, extensive fibrosis and immunosuppression present major challenges to developing treatments for pancreatic cancer. In this context, nanoparticles have been extensively studied as delivery platforms and adjuvants for cancer and other disease therapies. Recent advances in nanotechnology have led to the development of multiple nanocarrier-based formulations that not only improve drug delivery but also enhance immunotherapy-based approaches for pancreatic cancer. This review discusses and critically analyzes the novel nanoscale strategies that have been used for drug delivery and immunomodulation to improve treatment efficacy, including newly emerging immunotherapy-based approaches. This review also presents important perspectives on future research directions that will guide the rational design of novel and robust nanoscale platforms to treat pancreatic tumors, particularly with respect to targeted therapies and immunotherapies. These insights will inform the next generation of clinical treatments to help patients manage this debilitating disease and enhance survival rates.
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Liu, Luman, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad I. Wafa, John C. Christiansen, Brianna M. White et al. "Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies." Theranostics 12, no. 3 (2022): 1030-1060. DOI: This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. Copyright 2022 Ivyspring International Publisher. Posted with permission.
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pancreatic ductal adenocarcinoma, solid tumors, nanoparticles, drug delivery, immunotherapy, tumor microenvironment
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