Synthesis of a modified anthracycline 4,6,9,11-tetradeoxydaunomycinone

dc.contributor.author Kraus, George
dc.contributor.author Pezzanite, John
dc.contributor.author Kraus, George
dc.contributor.department Chemistry
dc.date 2018-02-17T09:14:10.000
dc.date.accessioned 2020-06-30T01:22:14Z
dc.date.available 2020-06-30T01:22:14Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 1982
dc.date.issued 1982-10-01
dc.description.abstract <p>The preparation of a tetradeoxy anthracyclinone is described. The key reaction is the cyclization of the acetylenic coumarin 10 to anthraquinone 11. Interestingly, the related model system 12 failed to cyclize. The transformation of 11 into the desired compound 13 was effected by straightforward reactions. The key intramolecular cyclization reaction is also useful for the preparation of phthalide quinone 7.</p>
dc.description.comments <p>Reprinted (adapted) with permission from <em>The Journal of Organic Chemistry, </em>47(22); 4337-4340. Doi: <a href="http://dx.doi.org/10.1021/jo00143a034" target="_blank">10.1021/jo00143a034</a>. Copyright 1982 American Chemical Society.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/chem_pubs/702/
dc.identifier.articleid 1722
dc.identifier.contextkey 7958240
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath chem_pubs/702
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/15187
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/702/0-1982_KrausGA_ACS_License_SynthesisModified.pdf|||Sat Jan 15 01:40:55 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/chem_pubs/702/1982_KrausGA_SynthesisModified.pdf|||Sat Jan 15 01:40:56 UTC 2022
dc.source.uri 10.1021/jo00143a034
dc.subject.disciplines Chemistry
dc.subject.disciplines Environmental Chemistry
dc.subject.disciplines Inorganic Chemistry
dc.subject.disciplines Organic Chemistry
dc.subject.disciplines Other Chemistry
dc.subject.disciplines Polymer Chemistry
dc.title Synthesis of a modified anthracycline 4,6,9,11-tetradeoxydaunomycinone
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 773dd84a-1494-40ee-aebf-549f26a04a22
relation.isOrgUnitOfPublication 42864f6e-7a3d-4be3-8b5a-0ae3c3830a11
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