Regeneration of neurosecretory axons into intrahypothalamic grafts of neural lobe, sciatic nerve, and optic nerve: a neurophysin-immunohistochemical, HRP-histochemical, and fine structural study

dc.contributor.advisor H. D. Dellmann
dc.contributor.author Ouassat, Mohammed
dc.contributor.department Veterinary Anatomy
dc.date 2018-08-23T11:13:25.000
dc.date.accessioned 2020-06-30T07:04:23Z
dc.date.available 2020-06-30T07:04:23Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 1992
dc.date.issued 1992
dc.description.abstract <p>To test the hypothesis that neurosecretory axon regeneration occurs only in the presence of specific vascular, perivascular, and glial microenvironments, isografts of neural lobe, optic nerve, and autografts of sciatic nerve were transplanted into the hypothalamo-neurohypophysial tract at the lateral retrochiasmatic area;The integrity of the BBB to intravenously administered HRP, the regenerative process of neurosecretory axons, and the functional recovery from the lesion-induced diabetes insipidus were analyzed at 18h, 36h, 10d, 30d, and 80d postsurgery;Neurophysin-positive axons invaded all grafts, as well as perivascular spaces of the adjacent hypothalamus. This neurosecretory axon regeneration was observed only in areas of the grafts or the surrounding hypothalamic tissue where the BBB was breached. Reestablishment of the BBB was paralleled by a decrease in both density and staining intensity of regenerating neurophysin-positive axons. The vast majority of regenerating neurosecretory axons was associated with glial cell types characteristic for each graft type;These observations illustrate that neurosecretory axon regeneration is tributary of the absence of BBB. It is speculated that blood-borne factors, provided during the time when the BBB is breached, initiate and sustain neurosecretory axon regeneration. In addition, products of glial element may enhance or complement the above stimulatory processes.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/rtd/10384/
dc.identifier.articleid 11383
dc.identifier.contextkey 6399892
dc.identifier.doi https://doi.org/10.31274/rtd-180813-9690
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath rtd/10384
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/63524
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/rtd/10384/r_9302012.pdf|||Fri Jan 14 18:19:43 UTC 2022
dc.subject.disciplines Anatomy
dc.subject.disciplines Animal Structures
dc.subject.disciplines Neuroscience and Neurobiology
dc.subject.disciplines Veterinary Anatomy
dc.subject.disciplines Veterinary Medicine
dc.subject.keywords Veterinary anatomy
dc.title Regeneration of neurosecretory axons into intrahypothalamic grafts of neural lobe, sciatic nerve, and optic nerve: a neurophysin-immunohistochemical, HRP-histochemical, and fine structural study
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication a4121e11-f085-4644-b87b-31ac92e3d3c7
thesis.degree.level dissertation
thesis.degree.name Doctor of Philosophy
File
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
r_9302012.pdf
Size:
5.06 MB
Format:
Adobe Portable Document Format
Description: