Analysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza

dc.contributor.author Xu, Haibin
dc.contributor.author Peters, Reuben
dc.contributor.author Peters, Reuben
dc.contributor.department Biochemistry, Biophysics and Molecular Biology
dc.date 2020-04-01T21:25:00.000
dc.date.accessioned 2020-06-29T23:46:55Z
dc.date.available 2020-06-29T23:46:55Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 2016
dc.date.issued 2016-06-01
dc.description.abstract <p>Salvia miltiorrhiza Bunge (Danshen) is a medicinal plant of the Lamiaceae family, and its dried roots have long been used in traditional Chinese medicine with hydrophilic phenolic acids and tanshinones as pharmaceutically active components (Xu et al., 2016; Zhang et al., 2014). The first step of tanshinone biosynthesis is the bicyclization of the general diterpene precursor (E, E, E)-geranylgeranyl diphosphate (GGPP) to copalyl diphosphate (CPP) by CPP synthases (CPSs), which is followed by cyclization or rearrangement reaction catalyzed by kaurene synthase-like enzymes (KSL). The resulting intermediate is usually an olefin, which requires the insertion of oxygen by cytochrome P450 mono-oxygenases (CYPs) for the final production of diterpenoids (Zi et al., 2014). While the CPS, KSL and several early acting CYPs (CYP76AH1, CYP76AH3 and CYP76AK1) for tanshinone biosynthesis have been identified in S. miltiorrhiza (Gao et al., 2009; Guo et al., in press; Guo et al., 2013; Zi and Peters, 2013), the majority of the overall biosynthetic pathway, as well as the relevant regulatory factors associated with tanshinone production, remains elusive (Figure 1B).</p>
dc.description.comments <p>This is a manuscript of a letter published as Xu, Haibin, Jingyuan Song, Hongmei Luo, Yujun Zhang, Qiushi Li, Yingjie Zhu, Jiang Xu et al. "Analysis of the genome sequence of the medicinal plant Salvia miltiorrhiza." <em>Molecular plant</em> 9, no. 6 (2016): 949-952. doi: <a href="https://doi.org/10.1016/j.molp.2016.03.010">10.1016/j.molp.2016.03.010</a>. Posted with permission.</p>
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dc.identifier archive/lib.dr.iastate.edu/bbmb_ag_pubs/269/
dc.identifier.articleid 1274
dc.identifier.contextkey 17169485
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath bbmb_ag_pubs/269
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/10741
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/bbmb_ag_pubs/269/2016_Peters_AnalysisGenomeManuscript.pdf|||Fri Jan 14 23:04:29 UTC 2022
dc.source.uri 10.1016/j.molp.2016.03.010
dc.subject.disciplines Biochemistry, Biophysics, and Structural Biology
dc.subject.disciplines Genetics and Genomics
dc.subject.disciplines Plant Sciences
dc.title Analysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza
dc.type article
dc.type.genre letter
dspace.entity.type Publication
relation.isAuthorOfPublication 498a24ec-81d7-4bee-b145-323d38e7a392
relation.isOrgUnitOfPublication c70f85ae-e0cd-4dce-96b5-4388aac08b3f
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